Literature summary extracted from

MacRae, I.J.; Segel, I.H.
Adenosine 5'-phosphosulfate (APS) kinase: diagnosing the mechanism of substrate inhibition (1999), Arch. Biochem. Biophys., 361, 277-282.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.1.25	adenosine 5'-phosphosulfate	-	Penicillium chrysogenum

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.7.1.25	0.0008	-	adenosine 5'-phosphosulfate	pH 8.1, 30°C	Penicillium chrysogenum
2.7.1.25	0.8	-	ATP	pH 8.1, 30°C	Penicillium chrysogenum
2.7.1.25	0.8	-	ATP	ATP in form of MgATP2-	Penicillium chrysogenum

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.25	Penicillium chrysogenum	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.1.25	ATP + adenosine 5-phosphosulfate	i.e. adenylylsulfate or APS	Penicillium chrysogenum	ADP + 3'-phosphoadenosine 5'-phosphosulfate	i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate	?
2.7.1.25	ATP + adenylyl sulfate	-	Penicillium chrysogenum	ADP + 3'-phosphoadenylyl sulfate	-	r

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
2.7.1.25	0.013	-	adenosine 5'-phosphosulfate	pH 8.1, 30°C	Penicillium chrysogenum

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Release 2023.1 (January 2023)