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Literature summary extracted from

  • Gray, J.C.; Kekwick, R.G.O.
    The inhibition of plant mevalonate kinase preparations by prenyl pyrophosphates (1972), Biochim. Biophys. Acta, 279, 290-296.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.36 farnesyl diphosphate
-
 Cucumis melo
2.7.1.36 farnesyl diphosphate
-
 Hevea brasiliensis
2.7.1.36 farnesyl diphosphate
-
 Phaseolus vulgaris
2.7.1.36 farnesyl diphosphate
-
 Saccharomyces cerevisiae
2.7.1.36 geranyl diphosphate
-
 Cucumis melo
2.7.1.36 geranyl diphosphate
-
 Hevea brasiliensis
2.7.1.36 geranyl diphosphate
-
 Phaseolus vulgaris
2.7.1.36 geranyl diphosphate
-
 Saccharomyces cerevisiae
2.7.1.36 geranylgeranyl diphosphate
-
 Cucumis melo
2.7.1.36 geranylgeranyl diphosphate
-
 Hevea brasiliensis
2.7.1.36 geranylgeranyl diphosphate
-
 Phaseolus vulgaris
2.7.1.36 geranylgeranyl diphosphate
-
 Saccharomyces cerevisiae
2.7.1.36 phytyl diphosphate
-
 Cucumis melo
2.7.1.36 phytyl diphosphate
-
 Hevea brasiliensis
2.7.1.36 phytyl diphosphate
-
 Phaseolus vulgaris
2.7.1.36 phytyl diphosphate
-
 Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.36 1.5
-
 ATP pH 7.0, 30°C Phaseolus vulgaris
2.7.1.36 2
-
 ATP pH 7.0, 30°C Hevea brasiliensis
2.7.1.36 5.4
-
 ATP pH 7.0, 30°C Cucumis melo
2.7.1.36 7.4
-
 ATP pH 7.0, 30°C Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.36 Cucumis melo
-
-
-
2.7.1.36 Hevea brasiliensis
-
-
-
2.7.1.36 Phaseolus vulgaris
-
-
-
2.7.1.36 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.36 cotyledon
-
 Phaseolus vulgaris
-
2.7.1.36 cotyledon
-
 Cucumis melo
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.36 0.014
-
-
 Cucumis melo
2.7.1.36 0.084
-
-
 Phaseolus vulgaris
2.7.1.36 0.42
-
-
 Hevea brasiliensis
2.7.1.36 0.77
-
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.36 ATP + mevalonate
-
 Phaseolus vulgaris ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Saccharomyces cerevisiae ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Hevea brasiliensis ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Cucumis melo ADP + phosphomevalonate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.36 0.0013
-
 farnesyl diphosphate pH 7.0, 30°C Saccharomyces cerevisiae
2.7.1.36 0.0023
-
 geranyl diphosphate pH 7.0, 30°C Saccharomyces cerevisiae
2.7.1.36 0.0036
-
 phytyl diphosphate pH 7.0, 30°C Phaseolus vulgaris
2.7.1.36 0.0039
-
 phytyl diphosphate pH 7.0, 30°C Hevea brasiliensis
2.7.1.36 0.0052
-
 farnesyl diphosphate pH 7.0, 30°C Hevea brasiliensis
2.7.1.36 0.0071
-
 farnesyl diphosphate pH 7.0, 30°C Phaseolus vulgaris
2.7.1.36 0.009
-
 phytyl diphosphate pH 7.0, 30°C Saccharomyces cerevisiae
2.7.1.36 0.011
-
 farnesyl diphosphate pH 7.0, 30°C Cucumis melo
2.7.1.36 0.016
-
 phytyl diphosphate pH 7.0, 30°C Cucumis melo
2.7.1.36 0.018
-
 geranyl diphosphate pH 7.0, 30°C Hevea brasiliensis
2.7.1.36 0.022
-
 geranylgeranyl diphosphate pH 7.0, 30°C Saccharomyces cerevisiae
2.7.1.36 0.028
-
 geranyl diphosphate pH 7.0, 30°C Cucumis melo
2.7.1.36 0.031
-
 geranyl diphosphate pH 7.0, 30°C Phaseolus vulgaris
2.7.1.36 0.049
-
 geranylgeranyl diphosphate pH 7.0, 30°C Phaseolus vulgaris
2.7.1.36 0.049
-
 geranylgeranyl diphosphate pH 7.0, 30°C Hevea brasiliensis
2.7.1.36 0.115
-
 geranylgeranyl diphosphate pH 7.0, 30°C Cucumis melo