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Literature summary extracted from
- Kinetic properties of arachidonoyl-coenzyme A synthetase in rat brain microsomes (1983), Arch. Biochem. Biophys., 226, 125-133.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 6.2.1.15 | arachidonate | unlabeled arachidonate inhibits arachidonate activation | Rattus norvegicus |  |
| 6.2.1.15 | docosahexaenoate | unlabeled | Rattus norvegicus | |
| 6.2.1.15 | oleate | - |
Rattus norvegicus | |
| 6.2.1.15 | palmitate | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 6.2.1.15 | 0.008 | - |
CoA | - |
Rattus norvegicus | |
| 6.2.1.15 | 0.036 | - |
arachidonate | - |
Rattus norvegicus | |
| 6.2.1.15 | 0.154 | - |
ATP | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 6.2.1.15 | microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 6.2.1.15 | Mg2+ | MgCl2 enhances activity | Rattus norvegicus | |
| 6.2.1.15 | Mg2+ | Km: 0.182 mM | Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 6.2.1.15 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 6.2.1.15 | brain | microvessels | Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 6.2.1.15 | ATP + arachidonate + CoA | - |
Rattus norvegicus | AMP + diphosphate + arachidonoyl-CoA | - |
? | |
| 6.2.1.15 | ATP + docosahexaenoate + CoA | - |
Rattus norvegicus | ATP + diphosphate + docosahexaenoyl-CoA | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 6.2.1.15 | 40 | - |
- |
Rattus norvegicus |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 6.2.1.15 | 45 | - |
half-life: 0.9 min | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 6.2.1.15 | 8.5 | - |
- |
Rattus norvegicus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 6.2.1.15 | 7 | 9.5 | 7: about 50% of maximal activity, 9.5: about 70% of maximal activity | Rattus norvegicus |
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Release 2023.1 (January 2023)
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