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Literature summary extracted from
- Enzymic synthesis of steroid sulphates. VIII. Inhibition of estrogen sulphotransferase by retinoic acid and free fatty acids (1972), Biochim. Biophys. Acta, 260, 724-730.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.8.2.4 | 3'-AMP | - |
Bos taurus |  |
| 2.8.2.4 | adenosine 5'-phosphosulfate | - |
Bos taurus | |
| 2.8.2.4 | adenosine 5'-sulfate | - |
Bos taurus | |
| 2.8.2.4 | cetyltrimethylammonium bromide | - |
Bos taurus | |
| 2.8.2.4 | fatty acid | unsaturated fatty acid of chain length C11-C14 | Bos taurus | |
| 2.8.2.4 | myristate | inhibition is non-competitive with respect to the substrate estrone | Bos taurus | |
| 2.8.2.4 | retinoic acid | - |
Bos taurus | |
| 2.8.2.4 | Sodium dodecyl sulfate | - |
Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.8.2.4 | 0.0027 | - |
estrone | pH 7.5, 37°C | Bos taurus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.8.2.4 | 3'-phosphoadenylylsulfate + estrone | Bos taurus | - |
adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.8.2.4 | Bos taurus | - |
bovine | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 2.8.2.4 | - |
Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.8.2.4 | adrenal gland | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.8.2.4 | 3'-phosphoadenylylsulfate + estrone | - |
Bos taurus | adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
r | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.8.2.4 | 1.49 | - |
adenosine 5'-phosphosulfate | pH 7.5, 37°C | Bos taurus | |
| 2.8.2.4 | 3.37 | - |
3'-AMP | pH 7.5, 37°C | Bos taurus | |
| 2.8.2.4 | 5 | - |
3'-AMP | pH 7.5, 37°C | Bos taurus | |
| 2.8.2.4 | 5 | - |
adenosine 5'-sulfate | pH 7.5, 37°C | Bos taurus | |
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Release 2023.1 (January 2023)
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