EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.2.2 | Clofibrate | isozymes CTE-I and MTE-I are induced, induction is completely dependent on PPARalpha | Mus musculus | |
3.1.2.2 | Clofibrate | induction of all 4 isozymes, mediated through a strictly peroxisome proliferator-activated receptor alpha, PPARalpha, function in gene regulation | Mus musculus | |
3.1.2.2 | additional information | fat fasting rapidly induces all isozymes, rapidly reversible | Mus musculus | |
3.1.2.2 | peroxisome proliferator-activated receptor alpha | induction of the isozymes in the liver | Mus musculus | |
3.1.2.2 | PPARalpha | internal receptor protein essential for effect of stimulating compounds | Mus musculus | |
3.1.2.2 | PPARalpha | gene expression inducing and regulatory role, mediates the stimulation by clofibrate | Mus musculus | |
3.1.2.2 | PPARalpha | i.e. peroxisome proliferator-activated receptor alpha | Mus musculus | |
3.1.2.20 | Clofibrate | isozymes CTE-I and MTE-I are induced, induction is completely dependent on PPARalpha | Mus musculus | |
3.1.2.20 | PPARalpha | internal receptor protein essential for effect of stimulating compounds | Mus musculus | |
3.1.2.20 | PPARalpha | gene expression inducing and regulatory role, mediates the stimulation by clofibrate | Mus musculus | |
3.1.2.20 | PPARalpha | i.e. peroxisome proliferator-activated receptor alpha | Mus musculus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.2.2 | - |
Mus musculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.2.2 | additional information | PPARalpha-null mice are not stimulated by clofibrate | Mus musculus |
3.1.2.20 | additional information | PPARalpha-null mice are not stimulated by clofibrate | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.2.2 | cytosol | isozyme CTE I | Mus musculus | 5829 | - |
3.1.2.2 | cytosol | isozyme CTE-I, diurnal regulation and regulation by fat content of the diet | Mus musculus | 5829 | - |
3.1.2.2 | mitochondrion | isozyme MTE I | Mus musculus | 5739 | - |
3.1.2.2 | mitochondrion | isozyme MTE-I | Mus musculus | 5739 | - |
3.1.2.2 | peroxisome | isozymes PTE-Ia and PTE-Ib | Mus musculus | 5777 | - |
3.1.2.2 | peroxisome | isozmes PTE-Ia and PTE-Ib | Mus musculus | 5777 | - |
3.1.2.20 | cytosol | isozyme CTE I | Mus musculus | 5829 | - |
3.1.2.20 | mitochondrion | isozyme MTE I | Mus musculus | 5739 | - |
3.1.2.20 | peroxisome | isozymes PTE-Ia and PTE-Ib | Mus musculus | 5777 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.2.2 | acyl-CoA + H2O | Mus musculus | involved in fatty acid metabolism | CoA + a carboxylate | - |
? | |
3.1.2.2 | additional information | Mus musculus | enzyme regulation | ? | - |
? | |
3.1.2.2 | additional information | Mus musculus | isozyme CTE-I: diurnal regulation and regulation by fat content of the diet | ? | - |
? | |
3.1.2.20 | acyl-CoA + H2O | Mus musculus | involved in fatty acid metabolism | CoA + a carboxylate | - |
? | |
3.1.2.20 | additional information | Mus musculus | enzyme regulation | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.2.2 | Mus musculus | - |
isozymes: cytosolic CTE-I, mitochondrial MTE-I | - |
3.1.2.2 | Mus musculus | - |
isozymes peroxisomal PTE-Ia and PTE-Ib | - |
3.1.2.2 | Mus musculus | - |
4 peroxisome proliferator-induced genes, isozymes CTE-I, MTE-I, PTE-Ia, and PTE-Ib | - |
3.1.2.20 | Mus musculus | - |
isozymes: cytosolic CTE-I, mitochondrial MTE-I | - |
3.1.2.20 | Mus musculus | - |
isozymes peroxisomal PTE-Ia and PTE-Ib | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.2.2 | liver | - |
Mus musculus | - |
3.1.2.20 | liver | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.2.2 | acyl-CoA + H2O | - |
Mus musculus | CoA + a carboxylate | - |
? | |
3.1.2.2 | acyl-CoA + H2O | involved in fatty acid metabolism | Mus musculus | CoA + a carboxylate | - |
? | |
3.1.2.2 | additional information | enzyme regulation | Mus musculus | ? | - |
? | |
3.1.2.2 | additional information | isozyme CTE-I: diurnal regulation and regulation by fat content of the diet | Mus musculus | ? | - |
? | |
3.1.2.2 | palmitoyl-CoA + H2O | - |
Mus musculus | CoA + palmitate | - |
? | |
3.1.2.20 | acyl-CoA + H2O | - |
Mus musculus | CoA + a carboxylate | - |
? | |
3.1.2.20 | acyl-CoA + H2O | involved in fatty acid metabolism | Mus musculus | CoA + a carboxylate | - |
? | |
3.1.2.20 | additional information | enzyme regulation | Mus musculus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.2.2 | CTE-I | - |
Mus musculus |
3.1.2.2 | long-chain acyl-CoA thioesterase | - |
Mus musculus |
3.1.2.2 | MTE-I | - |
Mus musculus |
3.1.2.2 | PTE-Ia | - |
Mus musculus |
3.1.2.2 | PTE-Ib | - |
Mus musculus |