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Literature summary extracted from

  • Kasuya, F.; Hiasa, M.; Kawai, Y.; Igarashi, K.; Fukui, M.
    Inhibitory effect of quinolone antimicrobial and nonsteroidal anti-inflammatory drugs on a medium chain acyl-CoA synthetase (2001), Biochem. Pharmacol., 62, 363-367.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.2 2-hydroxydodecanoic acid competitive; potent Mus musculus
6.2.1.2 2-Hydroxynaphthoic acid competitive; potent Mus musculus
6.2.1.2 diflunisal competitive; potent Mus musculus
6.2.1.2 enoxacin potent, mixed-type inhibition Mus musculus
6.2.1.2 felbinac inhibits activity with hexanoic acid, IC50: 0.025 mM Mus musculus
6.2.1.2 Nalidixic acid competitive; potent Mus musculus
6.2.1.2 ofloxacin potent, mixed-type inhibition Mus musculus
6.2.1.2 salicylic acid competitive; potent Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.2 mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.2 additional information Mus musculus the enzyme catalyzes the first reaction of glycine conjugation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.2 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.2.1.2
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.2 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.2 ATP + hexanoate + CoA 15% of the activity with octanoate Mus musculus AMP + diphosphate + hexanoyl-CoA
-
 ?
6.2.1.2 additional information the enzyme catalyzes the first reaction of glycine conjugation Mus musculus ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.2.1.2 0.0006
-
 diflunisal pH 8.5, 37°C Mus musculus
6.2.1.2 0.0124
-
 Nalidixic acid pH 8.5, 37°C Mus musculus
6.2.1.2 0.0134
-
 2-Hydroxynaphthoic acid pH 8.5, 37°C Mus musculus
6.2.1.2 0.015
-
 2-hydroxydodecanoic acid pH 8.5, 37°C Mus musculus
6.2.1.2 0.0196
-
 salicylic acid pH 8.5, 37°C Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.2.1.2 0.025
-
 inhibits activity with hexanoic acid, IC50: 0.025 mM Mus musculus felbinac