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Literature summary extracted from

  • Bergstrom, J.D.; Wong, G.A.; Edwards, P.A.; Edmond, J.
    The regulation of acetoacetyl-CoA synthetase activity by modulators of cholesterol synthesis in vivo and the utilization of acetoacetate for cholesterogenesis (1984), J. Biol. Chem., 259, 14548-14553.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.16 cytoplasm
-
 Rattus norvegicus 5737
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.16 additional information Rattus norvegicus primary role of acetoacetate as a substrate in lipogenesis is to promote cholesterol biosynthesis. Regulation of acetoacetyl-CoA synthetase is synchronized with the regulation of cholesterol biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.16 Rattus norvegicus
-
-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.16 liver
-
 Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.16 ATP + acetoacetate + CoA
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 Rattus norvegicus AMP + diphosphate + acetoacetyl-CoA
-
 ?
6.2.1.16 additional information primary role of acetoacetate as a substrate in lipogenesis is to promote cholesterol biosynthesis. Regulation of acetoacetyl-CoA synthetase is synchronized with the regulation of cholesterol biosynthesis Rattus norvegicus ?
-
 ?