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Literature summary extracted from

  • Mokashi, V.; Singh, D.K.; Porter, T.D.
    Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro (2005), Arch. Biochem. Biophys., 433, 474-480.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.34 supernatant protein factor i.e. SPF, a 46 kDa cytosolic protein, stimulation of squalene monooxygenase and cholesterol biosynthesis in hepatoma cell culture, acts directly on the enzyme, not by increasing the enzyme amount Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.34 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Rattus norvegicus rate-limiting step of cholesterol biosynthesis mevalonolactone + CoA + 2 NADP+ + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.34 McA-RH7777 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 Rattus norvegicus mevalonolactone + CoA + 2 NADP+ + H2O
-
 r
1.1.1.34 3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ rate-limiting step of cholesterol biosynthesis Rattus norvegicus mevalonolactone + CoA + 2 NADP+ + H2O
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 HMG-CoA reductase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.34 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.34 7.5
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH
-
 Rattus norvegicus