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Literature summary extracted from

  • Pinheiro de Carvalho, M.A.A.; Popova, T.N.; Dos Santos, T.M.M.; Zherebtsov, N.A.
    Effect of metabolites of gamma-aminobutyric shunt on activities of NAD- and NADP-isocitrate dehydrogenases and aconitate hydratase from higher plants (2003), Biol. Bull., 30, 236-242.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.41 additional information enzyme is not affected by gamma-aminobutyric acid Zea mays
1.1.1.42 glutamate
-
 Pisum sativum
1.1.1.42 glutamate
-
 Zea mays
1.1.1.42 additional information enzyme is not affected by gamma-aminobutyric acid and succinate Pisum sativum
1.1.1.42 additional information enzyme is not affected by gamma-aminobutyric acid and succinate Zea mays
1.1.1.42 succinic acid
-
 Pisum sativum
1.1.1.42 succinic acid
-
 Zea mays

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.41 gamma-aminobutyric acid slight inhibition Pisum sativum
1.1.1.41 glutamate slight inhibition Pisum sativum
1.1.1.41 additional information enzyme is not affected by gamma-aminobutyric acid and glutamate Zea mays
1.1.1.41 succinate slight inhibition Pisum sativum
1.1.1.41 succinate slight inhibition Zea mays
1.1.1.41 Succinic semialdehyde slight inhibition Pisum sativum
1.1.1.41 Succinic semialdehyde slight inhibition Zea mays
1.1.1.42 additional information enzyme is not affected by gamma-aminobutyric acid and succinate Pisum sativum
1.1.1.42 additional information enzyme is not affected by gamma-aminobutyric acid and succinate Zea mays

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.41 mitochondrion exclusively Pisum sativum 5739
-
1.1.1.42 cytosol
-
 Pisum sativum 5829
-
1.1.1.42 cytosol
-
 Zea mays 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.41 Mn2+
-
 Pisum sativum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.41 isocitrate + NAD+ Pisum sativum
-
 2-oxoglutarate + CO2 + NADH + H+
-
 ?
1.1.1.41 isocitrate + NAD+ Zea mays
-
 2-oxoglutarate + CO2 + NADH + H+
-
 ?
1.1.1.42 isocitrate + NADP+ Pisum sativum
-
 2-oxoglutarate + CO2 + NADPH + H+
-
 ?
1.1.1.42 isocitrate + NADP+ Zea mays
-
 2-oxoglutarate + CO2 + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.41 Pisum sativum
-
-
-
1.1.1.41 Zea mays
-
-
-
1.1.1.42 Pisum sativum
-
-
-
1.1.1.42 Zea mays
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.41 leaf
-
 Pisum sativum
-
1.1.1.41 scutellum
-
 Zea mays
-
1.1.1.42 leaf
-
 Pisum sativum
-
1.1.1.42 scutellum
-
 Zea mays
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.41 1.7
-
-
 Pisum sativum
1.1.1.41 2.9
-
-
 Zea mays
1.1.1.42 27.2
-
 purified enzyme Pisum sativum
1.1.1.42 34.6
-
 purified enzyme Zea mays

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.41 isocitrate + NAD+
-
 Pisum sativum 2-oxoglutarate + CO2 + NADH + H+
-
 ?
1.1.1.41 isocitrate + NAD+
-
 Zea mays 2-oxoglutarate + CO2 + NADH + H+
-
 ?
1.1.1.42 isocitrate + NADP+
-
 Pisum sativum 2-oxoglutarate + CO2 + NADPH + H+
-
 ?
1.1.1.42 isocitrate + NADP+
-
 Zea mays 2-oxoglutarate + CO2 + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.41 NAD-ICDH
-
 Pisum sativum
1.1.1.41 NAD-ICDH
-
 Zea mays
1.1.1.41 NAD-isocitrate dehydrogenase
-
 Pisum sativum
1.1.1.41 NAD-isocitrate dehydrogenase
-
 Zea mays
1.1.1.42 NADP-ICDH
-
 Pisum sativum
1.1.1.42 NADP-ICDH
-
 Zea mays
1.1.1.42 NADP-specific isocitrate dehydrogenase
-
 Pisum sativum
1.1.1.42 NADP-specific isocitrate dehydrogenase
-
 Zea mays

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.41 25
-
 assay at Pisum sativum
1.1.1.41 25
-
 assay at Zea mays
1.1.1.42 25
-
 assay at Pisum sativum
1.1.1.42 25
-
 assay at Zea mays

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.41 NAD+ specific for Pisum sativum
1.1.1.41 NAD+ specific for Zea mays
1.1.1.42 NADP+ specific for Pisum sativum
1.1.1.42 NADP+ specific for Zea mays