Any feedback?
Literature summary extracted from
- Tissue-specific developmental requirements of Drosophila tyrosine hydroxylase isoforms (2003), Genesis, 35, 175-184.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.16.2 | additional information | Drosophila melanogaster | key enzyme in dopamine biosynthesis | ? | - |
? |  |
| 1.14.16.2 | additional information | Drosophila melanogaster | key enzyme in dopamine biosynthesis. Tissue-specific expression of the isoenzymes generated through alternative splicing of the tyrosine hydroxylase gene is a vital step in Drosophila development | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.16.2 | Drosophila melanogaster | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.16.2 | central nervous system | isoenzyme DHT1 is selectively expressed in central nervous system. DTH1 cannot perform the function of the DTH II in the hypoderm | Drosophila melanogaster | - |
| 1.14.16.2 | hypodermis | isoenzyme DHT2 is selectively expressed in central nervous system. DTH1 cannot perform the function of the DTH II in the hypoderm | Drosophila melanogaster | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.16.2 | L-tyrosine + (6R)-5,6,7,8-tetrahydrobiopterin + O2 | - |
Drosophila melanogaster | 3,4-dihydroxyphenylalanine + ? | - |
? | |
| 1.14.16.2 | additional information | key enzyme in dopamine biosynthesis | Drosophila melanogaster | ? | - |
? | |
| 1.14.16.2 | additional information | key enzyme in dopamine biosynthesis. Tissue-specific expression of the isoenzymes generated through alternative splicing of the tyrosine hydroxylase gene is a vital step in Drosophila development | Drosophila melanogaster | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.16.2 | DTH1 | - |
Drosophila melanogaster |
| 1.14.16.2 | DTH2 | - |
Drosophila melanogaster |
| 1.14.16.2 | tyrosine hydroxylase | - |
Drosophila melanogaster |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.16.2 | (6R)-5,6,7,8-tetrahydrobiopterin | - |
Drosophila melanogaster | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
