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Literature summary extracted from

  • Hoang, T.T.; Schweizer, H.P.
    Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis (1999), J. Bacteriol., 181, 5489-5497.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.9
-
 Pseudomonas aeruginosa

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.9 G95V mutant enzyme retains normal activity with enoyl-[acyl-carrier-protein], but is highly resistant to triclosan Pseudomonas aeruginosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 triclosan
-
 Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Pseudomonas aeruginosa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.9 polyhistidine-tagged recombinant wild-type protein and mutant enzyme G95V Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.9 crotonyl-CoA + NADH
-
 Pseudomonas aeruginosa butyryl-CoA + NAD+
-
 ?
1.3.1.9 crotonyl-[acyl-carrier protein] + NADH activity is 5.9fold higher than with crotonyl-CoA Pseudomonas aeruginosa butyryl-[acyl-carrier protein] + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 enoyl-ACP reductase
-
 Pseudomonas aeruginosa
1.3.1.9 enoyl-acyl carrier protein reductase
-
 Pseudomonas aeruginosa
1.3.1.9 FabI
-
 Pseudomonas aeruginosa

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.9 additional information no activity with NADPH Pseudomonas aeruginosa
1.3.1.9 NADH dependent on Pseudomonas aeruginosa