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Literature summary extracted from

  • Derbyshire, E.R.; Tran, R.; Mathies, R.A.; Marletta, M.A.
    Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase (2005), Biochemistry, 44, 16257-16265.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.2 CO 2fold activation in absence of 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole, 115fold activation in presence of 0.15 mM 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole Rattus norvegicus
4.6.1.2 nitrosobutane 6fold activation in absence of 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole, 47fold activation in presence of 0.15 mM 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole Rattus norvegicus
4.6.1.2 nitrosohexane 2fold activation in absence of 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole, 33fold activation in presence of 0.15 mM 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole Rattus norvegicus
4.6.1.2 nitrosooctane 2fold activation in absence of 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole, 11fold activation in presence of 0.15 mM 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole Rattus norvegicus
4.6.1.2 nitrosopentane 2fold activation in absence of 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole, 39fold activation in presence of 0.15 mM 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole Rattus norvegicus
4.6.1.2 nitrosopropane 2fold activation in absence of 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole, 45fold activation in presence of 0.15 mM 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole Rattus norvegicus
4.6.1.2 NO 127fold activation in absence of 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole, 211fold activation in presence of 0.15 mM 3-(5'-hydroxymethyl-3'-furyl)-1-benzylimidazole Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Rattus norvegicus
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