EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.22 | additional information | Cdk5 is activated by phosphorylation, integrin alpha1beta1 regulates phosphorylation of the axonal cytoskeleton protein | Homo sapiens | |
2.7.11.22 | p25 | regulatory subunit and activator of Cdk5, soluble, p35 is cleaved to p25 by calpain leading to hyperactivation of Cdk5 | Mus musculus | |
2.7.11.22 | p25 | regulatory subunit and activator of Cdk5, soluble, p35 is cleaved to p25 by calpain leading to hyperactivation of Cdk5 | Homo sapiens | |
2.7.11.22 | p35 | regulatory subunit and activator of Cdk5 | Rattus norvegicus | |
2.7.11.22 | p35 | regulatory subunit and activator of Cdk5 | Sus scrofa | |
2.7.11.22 | p35 | regulatory subunit and activator of Cdk5 | Canis lupus familiaris | |
2.7.11.22 | p35 | regulatory subunit and activator of Cdk5, membrane-bound, in neuronal growth cones, p35 is cleaved to p25 by calpain leading to hyperactivation of Cdk5 | Mus musculus | |
2.7.11.22 | p35 | regulatory subunit and activator of Cdk5, membrane-bound, in neuronal growth cones, p35 is cleaved to p25 by calpain leading to hyperactivation of Cdk5 | Homo sapiens | |
2.7.11.22 | p39 | regulatory subunit and activator of Cdk5 | Mus musculus | |
2.7.11.22 | p39 | regulatory subunit and activator of Cdk5 | Homo sapiens | |
2.7.11.22 | p39 | regulatory subunit and activator of Cdk5 | Rattus norvegicus | |
2.7.11.22 | p39 | regulatory subunit and activator of Cdk5 | Sus scrofa | |
2.7.11.22 | p39 | regulatory subunit and activator of Cdk5 | Canis lupus familiaris |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.11.22 | Cdk5, DNA sequence determination and analysis | Drosophila melanogaster |
2.7.11.22 | Cdk5, DNA sequence determination and analysis | Mus musculus |
2.7.11.22 | Cdk5, DNA sequence determination and analysis | Rattus norvegicus |
2.7.11.22 | Cdk5, DNA sequence determination and analysis | Sus scrofa |
2.7.11.22 | Cdk5, DNA sequence determination and analysis | Saccharomyces cerevisiae |
2.7.11.22 | Cdk5, DNA sequence determination and analysis | Canis lupus familiaris |
2.7.11.22 | Cdk5, DNA sequence determination and analysis | Caenorhabditis elegans |
2.7.11.22 | Cdk5, DNA sequence determination and analysis | Doryteuthis pealeii |
2.7.11.22 | Cdk5, DNA sequence determination and analysis | Danio rerio |
2.7.11.22 | Cdk5, DNA sequence determination and analysis, co-expression of Cdk5 and p35 in HEK293 cells | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.7.11.22 | additional information | construction of Cdk5-knockout mutant mice that are embryonically lethal with very few viable at birth dying a few hours postpartum, p35 and p39 double-knockout mutant mice show a similar phenotype, the KO mice show higher ERK1/2 activity and increased neurofilament phosphorylation | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.22 | additional information | integrin alpha1beta1 regulates phosphorylation of the axonal cytoskeleton protein, development of inhibitory peptides | Homo sapiens | |
2.7.11.22 | roscovitine | - |
Caenorhabditis elegans | |
2.7.11.22 | roscovitine | - |
Canis lupus familiaris | |
2.7.11.22 | roscovitine | - |
Danio rerio | |
2.7.11.22 | roscovitine | - |
Doryteuthis pealeii | |
2.7.11.22 | roscovitine | - |
Drosophila melanogaster | |
2.7.11.22 | roscovitine | Cdk5 inhibition induces neurotransmitter release in vivo | Homo sapiens | |
2.7.11.22 | roscovitine | - |
Mus musculus | |
2.7.11.22 | roscovitine | - |
Rattus norvegicus | |
2.7.11.22 | roscovitine | - |
Saccharomyces cerevisiae | |
2.7.11.22 | roscovitine | - |
Sus scrofa |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.11.22 | cytoplasm | - |
Homo sapiens | 5737 | - |
2.7.11.22 | cytoskeleton | neuronal | Drosophila melanogaster | 5856 | - |
2.7.11.22 | cytoskeleton | neuronal | Mus musculus | 5856 | - |
2.7.11.22 | cytoskeleton | neuronal | Homo sapiens | 5856 | - |
2.7.11.22 | cytoskeleton | neuronal | Rattus norvegicus | 5856 | - |
2.7.11.22 | cytoskeleton | neuronal | Sus scrofa | 5856 | - |
2.7.11.22 | cytoskeleton | neuronal | Canis lupus familiaris | 5856 | - |
2.7.11.22 | cytoskeleton | neuronal | Caenorhabditis elegans | 5856 | - |
2.7.11.22 | cytoskeleton | neuronal | Doryteuthis pealeii | 5856 | - |
2.7.11.22 | cytoskeleton | neuronal | Danio rerio | 5856 | - |
2.7.11.22 | Golgi apparatus | - |
Homo sapiens | 5794 | - |
2.7.11.22 | synapse | - |
Homo sapiens | 45202 | - |
2.7.11.22 | synaptosome | - |
Homo sapiens | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.22 | Mg2+ | - |
Canis lupus familiaris |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.22 | ATP + axonal cytoskeleton protein | Homo sapiens | regulated by integrin alpha1beta1 | ADP + phosphorylated axonal cytoskeleton protein | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | Mus musculus | i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | Homo sapiens | i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | Rattus norvegicus | i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | Sus scrofa | i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | Canis lupus familiaris | i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | Doryteuthis pealeii | i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + Cprk | Homo sapiens | i.e. Cdk5/p35-regulated kinase | ADP + phosphorylated Cprk | - |
? | |
2.7.11.22 | ATP + dephosphin | Homo sapiens | Cdk5 regulates endocytosis involving dephosphin activity, overview | ADP + phosphorylated dephosphin | - |
? | |
2.7.11.22 | ATP + ErbB2 | Mus musculus | phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin | ADP + phosphorylated ErbB2 | - |
? | |
2.7.11.22 | ATP + ErbB2 | Homo sapiens | phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin | ADP + phosphorylated ErbB2 | - |
? | |
2.7.11.22 | ATP + ErbB3 | Mus musculus | phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin | ADP + phosphorylated ErbB3 | - |
? | |
2.7.11.22 | ATP + ErbB3 | Homo sapiens | phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin | ADP + phosphorylated ErbB3 | - |
? | |
2.7.11.22 | ATP + MEK1 | Mus musculus | Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | Homo sapiens | Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | Rattus norvegicus | Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | Sus scrofa | Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | Canis lupus familiaris | Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | Doryteuthis pealeii | Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + Munc-18 | Homo sapiens | involved in regulation of exocytosis involving SNARE proteins, Munc-18 is required for mediating secretory responsesoverview | ADP + phosphorylated Munc-18 | - |
? | |
2.7.11.22 | ATP + NF-H | Mus musculus | neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | Homo sapiens | neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | Sus scrofa | neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | Rattus norvegicus | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | Canis lupus familiaris | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | Doryteuthis pealeii | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-M | Mus musculus | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | Homo sapiens | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | Rattus norvegicus | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | Sus scrofa | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | Canis lupus familiaris | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | Doryteuthis pealeii | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NR1 receptor | Homo sapiens | involved in synaptic transmission, overview | ADP + phosphorylated NR1 receptor | - |
? | |
2.7.11.22 | ATP + NR2 receptor | Homo sapiens | involved in synaptic transmission, phosphorylation of Ser1232 on the A subunit upregulates NMCAR activity, overview | ADP + phosphorylated NR2 receptor | - |
? | |
2.7.11.22 | ATP + tau protein | Mus musculus | hyperactivated Cdk5-p25 | ADP + phosphorylated tau protein | - |
? | |
2.7.11.22 | ATP + tau protein | Homo sapiens | hyperactivated Cdk5-p25 | ADP + phosphorylated tau protein | - |
? | |
2.7.11.22 | ATP + VGCC | Homo sapiens | a voltage-dependent calcium channel, phosphorylation within the intracellular loop of the channel inhibiting interaction with SNARE proteins, SNAP-25, and synaptotagmin I required for neurotransmitter release, overview | ADP + phosphorylated NR1 receptor | - |
? | |
2.7.11.22 | additional information | Drosophila melanogaster | Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins | ? | - |
? | |
2.7.11.22 | additional information | Caenorhabditis elegans | Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins | ? | - |
? | |
2.7.11.22 | additional information | Danio rerio | Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins | ? | - |
? | |
2.7.11.22 | additional information | Mus musculus | Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, and is critical for neuronal survival, deregulation of Cdk5 occurs in neurodegeneration | ? | - |
? | |
2.7.11.22 | additional information | Rattus norvegicus | Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration | ? | - |
? | |
2.7.11.22 | additional information | Sus scrofa | Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration | ? | - |
? | |
2.7.11.22 | additional information | Canis lupus familiaris | Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration | ? | - |
? | |
2.7.11.22 | additional information | Doryteuthis pealeii | Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration | ? | - |
? | |
2.7.11.22 | additional information | Homo sapiens | Cdk5 regulation, overview, Cdk5 regulates endocytosis through association with amphiphysin and dynamin, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.22 | Caenorhabditis elegans | - |
- |
- |
2.7.11.22 | Canis lupus familiaris | - |
- |
- |
2.7.11.22 | Danio rerio | - |
zebrafish | - |
2.7.11.22 | Doryteuthis pealeii | - |
common squid | - |
2.7.11.22 | Drosophila melanogaster | - |
- |
- |
2.7.11.22 | Homo sapiens | - |
- |
- |
2.7.11.22 | Mus musculus | - |
- |
- |
2.7.11.22 | Rattus norvegicus | - |
- |
- |
2.7.11.22 | Saccharomyces cerevisiae | - |
- |
- |
2.7.11.22 | Sus scrofa | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.11.22 | phosphoprotein | Cdk5 is regulated by reversible phosphorylation | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.22 | brain | - |
Mus musculus | - |
2.7.11.22 | brain | - |
Homo sapiens | - |
2.7.11.22 | brain | - |
Rattus norvegicus | - |
2.7.11.22 | brain | - |
Sus scrofa | - |
2.7.11.22 | brain | - |
Canis lupus familiaris | - |
2.7.11.22 | cerebellum | - |
Homo sapiens | - |
2.7.11.22 | cerebral cortex | - |
Mus musculus | - |
2.7.11.22 | nervous system | - |
Drosophila melanogaster | - |
2.7.11.22 | nervous system | - |
Mus musculus | - |
2.7.11.22 | nervous system | - |
Homo sapiens | - |
2.7.11.22 | nervous system | - |
Sus scrofa | - |
2.7.11.22 | nervous system | - |
Canis lupus familiaris | - |
2.7.11.22 | nervous system | - |
Caenorhabditis elegans | - |
2.7.11.22 | nervous system | - |
Doryteuthis pealeii | - |
2.7.11.22 | nervous system | - |
Danio rerio | - |
2.7.11.22 | neuroblastoma cell | - |
Homo sapiens | - |
2.7.11.22 | neuron | - |
Drosophila melanogaster | - |
2.7.11.22 | neuron | - |
Mus musculus | - |
2.7.11.22 | neuron | - |
Homo sapiens | - |
2.7.11.22 | neuron | - |
Rattus norvegicus | - |
2.7.11.22 | neuron | - |
Sus scrofa | - |
2.7.11.22 | neuron | - |
Canis lupus familiaris | - |
2.7.11.22 | neuron | - |
Caenorhabditis elegans | - |
2.7.11.22 | neuron | - |
Doryteuthis pealeii | - |
2.7.11.22 | neuron | - |
Danio rerio | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.22 | ATP + axonal cytoskeleton protein | - |
Homo sapiens | ADP + phosphorylated axonal cytoskeleton protein | - |
? | |
2.7.11.22 | ATP + axonal cytoskeleton protein | regulated by integrin alpha1beta1 | Homo sapiens | ADP + phosphorylated axonal cytoskeleton protein | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis | Mus musculus | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis | Homo sapiens | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis | Rattus norvegicus | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis | Sus scrofa | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis | Canis lupus familiaris | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | i.e. JNK3, phosphorylation inhibits JNK3 and leads to reduced phosphorylation of c-jun and to reduced apoptosis | Doryteuthis pealeii | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | i.e. JNK3, phosphorylation at Thr131 | Mus musculus | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | i.e. JNK3, phosphorylation at Thr131 | Homo sapiens | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | i.e. JNK3, phosphorylation at Thr131 | Rattus norvegicus | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | i.e. JNK3, phosphorylation at Thr131 | Sus scrofa | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | i.e. JNK3, phosphorylation at Thr131 | Canis lupus familiaris | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + c-Jun N-terminal kinase 3 | i.e. JNK3, phosphorylation at Thr131 | Doryteuthis pealeii | ADP + phosphorylated c-Jun N-terminal kinase 3 | - |
? | |
2.7.11.22 | ATP + Cprk | i.e. Cdk5/p35-regulated kinase | Homo sapiens | ADP + phosphorylated Cprk | - |
? | |
2.7.11.22 | ATP + dephosphin | - |
Homo sapiens | ADP + phosphorylated dephosphin | - |
? | |
2.7.11.22 | ATP + dephosphin | Cdk5 regulates endocytosis involving dephosphin activity, overview | Homo sapiens | ADP + phosphorylated dephosphin | - |
? | |
2.7.11.22 | ATP + ErbB2 | phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin | Mus musculus | ADP + phosphorylated ErbB2 | - |
? | |
2.7.11.22 | ATP + ErbB2 | phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin | Homo sapiens | ADP + phosphorylated ErbB2 | - |
? | |
2.7.11.22 | ATP + ErbB2 | phosphorylation at Thr871 | Mus musculus | ADP + phosphorylated ErbB2 | - |
? | |
2.7.11.22 | ATP + ErbB2 | phosphorylation at Thr871 | Homo sapiens | ADP + phosphorylated ErbB2 | - |
? | |
2.7.11.22 | ATP + ErbB3 | phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin | Mus musculus | ADP + phosphorylated ErbB3 | - |
? | |
2.7.11.22 | ATP + ErbB3 | phosphorylation of the neuregulin receptor by Cdk5 is involved in regulation of neuregulin | Homo sapiens | ADP + phosphorylated ErbB3 | - |
? | |
2.7.11.22 | ATP + ErbB3 | phosphorylation at Ser1120 | Mus musculus | ADP + phosphorylated ErbB3 | - |
? | |
2.7.11.22 | ATP + ErbB3 | phosphorylation at Ser1120 | Homo sapiens | ADP + phosphorylated ErbB3 | - |
? | |
2.7.11.22 | ATP + MEK1 | - |
Homo sapiens | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | - |
Rattus norvegicus | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | - |
Sus scrofa | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | - |
Canis lupus familiaris | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | - |
Doryteuthis pealeii | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview | Mus musculus | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview | Homo sapiens | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview | Rattus norvegicus | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview | Sus scrofa | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview | Canis lupus familiaris | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | Cdk5 regulates the ERK1/2 pathway through phosphorylation of MEK1, overview | Doryteuthis pealeii | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + MEK1 | phosphorylation at Thr286 | Mus musculus | ADP + phosphorylated MEK1 | - |
? | |
2.7.11.22 | ATP + Munc-18 | - |
Homo sapiens | ADP + phosphorylated Munc-18 | - |
? | |
2.7.11.22 | ATP + Munc-18 | involved in regulation of exocytosis involving SNARE proteins, Munc-18 is required for mediating secretory responsesoverview | Homo sapiens | ADP + phosphorylated Munc-18 | - |
? | |
2.7.11.22 | ATP + NF-H | neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | Mus musculus | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | Homo sapiens | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | neurofilament protein that correlates neurit outgrowth, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | Sus scrofa | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | Rattus norvegicus | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | Canis lupus familiaris | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | Doryteuthis pealeii | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | neurofilament protein, phosphorylation at the KSP repeats | Mus musculus | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | neurofilament protein, phosphorylation at the KSP repeats | Rattus norvegicus | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | neurofilament protein, phosphorylation at the KSP repeats | Sus scrofa | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | neurofilament protein, phosphorylation at the KSP repeats | Canis lupus familiaris | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | neurofilament protein, phosphorylation at the KSP repeats | Doryteuthis pealeii | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-H | neurofilament protein, phosphorylation at the KSP repeats, hyperactivated Cdk5-p25 | Homo sapiens | ADP + phosphorylated NF-H | - |
? | |
2.7.11.22 | ATP + NF-M | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | Mus musculus | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | Homo sapiens | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | Rattus norvegicus | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | Sus scrofa | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | Canis lupus familiaris | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | neurofilament protein, phosphorylation at the KSP repeats, regulated by the myelin-associate glycoprotein | Doryteuthis pealeii | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | neurofilament protein, phosphorylation at the KSP repeats | Mus musculus | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | neurofilament protein, phosphorylation at the KSP repeats | Rattus norvegicus | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | neurofilament protein, phosphorylation at the KSP repeats | Sus scrofa | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | neurofilament protein, phosphorylation at the KSP repeats | Canis lupus familiaris | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | neurofilament protein, phosphorylation at the KSP repeats | Doryteuthis pealeii | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NF-M | neurofilament protein, phosphorylation at the KSP repeats, hyperactivated Cdk5-p25 | Homo sapiens | ADP + phosphorylated NF-M | - |
? | |
2.7.11.22 | ATP + NR1 receptor | - |
Homo sapiens | ADP + phosphorylated NR1 receptor | - |
? | |
2.7.11.22 | ATP + NR1 receptor | involved in synaptic transmission, overview | Homo sapiens | ADP + phosphorylated NR1 receptor | - |
? | |
2.7.11.22 | ATP + NR2 receptor | involved in synaptic transmission, phosphorylation of Ser1232 on the A subunit upregulates NMCAR activity, overview | Homo sapiens | ADP + phosphorylated NR2 receptor | - |
? | |
2.7.11.22 | ATP + NR2 receptor | with phosphorylation sites on both, A and B subunits, e.g. Ser1232 on the A subunit | Homo sapiens | ADP + phosphorylated NR2 receptor | - |
? | |
2.7.11.22 | ATP + tau protein | hyperactivated Cdk5-p25 | Mus musculus | ADP + phosphorylated tau protein | - |
? | |
2.7.11.22 | ATP + tau protein | hyperactivated Cdk5-p25 | Homo sapiens | ADP + phosphorylated tau protein | - |
? | |
2.7.11.22 | ATP + VGCC | a voltage-dependent calcium channel, phosphorylation within the intracellular loop of the channel inhibiting interaction with SNARE proteins, SNAP-25, and synaptotagmin I required for neurotransmitter release, overview | Homo sapiens | ADP + phosphorylated NR1 receptor | - |
? | |
2.7.11.22 | ATP + VGCC | a voltage-dependent calcium channel, phosphorylation within the intracellular loop of the channel | Homo sapiens | ADP + phosphorylated NR1 receptor | - |
? | |
2.7.11.22 | additional information | Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins | Drosophila melanogaster | ? | - |
? | |
2.7.11.22 | additional information | Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins | Caenorhabditis elegans | ? | - |
? | |
2.7.11.22 | additional information | Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins | Danio rerio | ? | - |
? | |
2.7.11.22 | additional information | Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, and is critical for neuronal survival, deregulation of Cdk5 occurs in neurodegeneration | Mus musculus | ? | - |
? | |
2.7.11.22 | additional information | Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration | Rattus norvegicus | ? | - |
? | |
2.7.11.22 | additional information | Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration | Sus scrofa | ? | - |
? | |
2.7.11.22 | additional information | Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration | Canis lupus familiaris | ? | - |
? | |
2.7.11.22 | additional information | Cdk5 regulation, overview, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration | Doryteuthis pealeii | ? | - |
? | |
2.7.11.22 | additional information | Cdk5 regulation, overview, Cdk5 regulates endocytosis through association with amphiphysin and dynamin, Cdk5 is involved in neuronal migration and phosphorylation of neurofilaments and cytoskeletal proteins, deregulation of Cdk5 occurs in neurodegeneration | Homo sapiens | ? | - |
? | |
2.7.11.22 | additional information | Cdk5 associates with amphiphysin and dynamin | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.22 | Cdk5 | - |
Drosophila melanogaster |
2.7.11.22 | Cdk5 | - |
Mus musculus |
2.7.11.22 | Cdk5 | - |
Homo sapiens |
2.7.11.22 | Cdk5 | - |
Rattus norvegicus |
2.7.11.22 | Cdk5 | - |
Sus scrofa |
2.7.11.22 | Cdk5 | - |
Saccharomyces cerevisiae |
2.7.11.22 | Cdk5 | - |
Canis lupus familiaris |
2.7.11.22 | Cdk5 | - |
Caenorhabditis elegans |
2.7.11.22 | Cdk5 | - |
Doryteuthis pealeii |
2.7.11.22 | Cdk5 | - |
Danio rerio |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.22 | ATP | - |
Drosophila melanogaster | |
2.7.11.22 | ATP | - |
Mus musculus | |
2.7.11.22 | ATP | - |
Homo sapiens | |
2.7.11.22 | ATP | - |
Rattus norvegicus | |
2.7.11.22 | ATP | - |
Sus scrofa | |
2.7.11.22 | ATP | - |
Saccharomyces cerevisiae | |
2.7.11.22 | ATP | - |
Canis lupus familiaris | |
2.7.11.22 | ATP | - |
Caenorhabditis elegans | |
2.7.11.22 | ATP | - |
Doryteuthis pealeii | |
2.7.11.22 | ATP | - |
Danio rerio |