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Literature summary extracted from

  • Elased, K.M.; Cunha, T.S.; Gurley, S.B.; Coffman, T.M.; Morris, M.
    New mass spectrometric assay for angiotensin-converting enzyme 2 activity (2006), Hypertension, 47, 1010-1017.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.17.23 analysis mass spectrometric assay for angiotensin-converting enzyme 2 using angiotensin II as substrate will have applications in drug screening, antagonist development, and clinical investigations Mus musculus
3.4.17.23 analysis mass spectrometric assay for angiotensin-converting enzyme 2 using angiotensin II as substrate will have applications in drug screening, antagonist development, and clinical investigations Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 MLN 4760 IC50: 3 nM Homo sapiens
3.4.17.23 MLN 4760 IC50: 3 nM Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens
-
 recombinant
-
3.4.17.23 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 kidney
-
 Mus musculus
-
3.4.17.23 additional information no activity in plasma Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin II + H2O
-
 Mus musculus angiotensin-(1-7) + Phe
-
 ?
3.4.17.23 angiotensin II + H2O
-
 Homo sapiens angiotensin-(1-7) + Phe
-
 ?
3.4.17.23 additional information angiotensin I is not a good substrate for recombinant human ACE2 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Mus musculus
3.4.17.23 ACE2
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.17.23 0.000003
-
 IC50: 3 nM Mus musculus MLN 4760
3.4.17.23 0.000003
-
 IC50: 3 nM Homo sapiens MLN 4760