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Literature summary extracted from
- Uptake of the b-lactam precursor a-aminoadipic acid in Penicillium chrysogenum is mediated by the acidic and the general amino acid permease (2004), Appl. Environ. Microbiol., 70, 4775-4783.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 7.4.2.1 | expression in Saccharomyces cerevisiae mutant M4276 | Penicillium chrysogenum |
| 7.4.2.2 | expression in Saccharomyces cerevisiae mutant M4276 | Penicillium chrysogenum |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.4.2.1 | leucine | inhibits alpha-aminoadipic acid transport via PcGap1 | Penicillium chrysogenum |  |
| 7.4.2.2 | additional information | leucine does not inhibit alpha-aminoadipic acid transport via PcDIP5 | Penicillium chrysogenum |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 7.4.2.1 | 0.23 | - |
alpha-aminoadipic acid-[polar amino acid-binding protein][side 1] | - |
Penicillium chrysogenum | |
| 7.4.2.2 | 0.8 | - |
alpha-aminoadipic acid-[polar amino acid-binding protein][side 1] | - |
Penicillium chrysogenum |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.4.2.1 | Penicillium chrysogenum | - |
- |
- |
| 7.4.2.1 | Penicillium chrysogenum Wisconsin 54-1255 | - |
- |
- |
| 7.4.2.2 | Penicillium chrysogenum | - |
- |
- |
| 7.4.2.2 | Penicillium chrysogenum Wisconsin 54-1255 | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.4.2.1 | ATP + H2O + alpha-aminoadipic acid-[polar amino acid-binding protein][side 1] | - |
Penicillium chrysogenum | ADP + phosphate + alpha-aminoadipic acid[side 2] + [polar amino acid-binding protein][side 1] | - |
? | |
| 7.4.2.1 | ATP + H2O + alpha-aminoadipic acid-[polar amino acid-binding protein][side 1] | - |
Penicillium chrysogenum Wisconsin 54-1255 | ADP + phosphate + alpha-aminoadipic acid[side 2] + [polar amino acid-binding protein][side 1] | - |
? | |
| 7.4.2.1 | additional information | contributes to the alpha-aminoadipic acid flux | Penicillium chrysogenum | ? | - |
? | |
| 7.4.2.1 | additional information | contributes to the alpha-aminoadipic acid flux | Penicillium chrysogenum Wisconsin 54-1255 | ? | - |
? | |
| 7.4.2.2 | ATP + H2O + alpha-aminoadipic acid-[polar amino acid-binding protein][side 1] | - |
Penicillium chrysogenum | ADP + phosphate + alpha-aminoadipic acid[side 2] + [polar amino acid-binding protein][side 1] | - |
? | |
| 7.4.2.2 | ATP + H2O + alpha-aminoadipic acid-[polar amino acid-binding protein][side 1] | - |
Penicillium chrysogenum Wisconsin 54-1255 | ADP + phosphate + alpha-aminoadipic acid[side 2] + [polar amino acid-binding protein][side 1] | - |
? | |
| 7.4.2.2 | additional information | contributes to the alpha-aminoadipic acid flux | Penicillium chrysogenum | ? | - |
? | |
| 7.4.2.2 | additional information | contributes to the alpha-aminoadipic acid flux | Penicillium chrysogenum Wisconsin 54-1255 | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.4.2.1 | general amino acid permease | - |
Penicillium chrysogenum |
| 7.4.2.1 | PcGap1 | - |
Penicillium chrysogenum |
| 7.4.2.2 | acidic amino acid permease | - |
Penicillium chrysogenum |
| 7.4.2.2 | PcDIP5 | - |
Penicillium chrysogenum |
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