Literature summary extracted from

Martin, F.; Linden, T.; Katschinski, D.M.; Oehme, F.; Flamme, I.; Mukhopadhyay, C.K.; Eckhardt, K.; Troeger, J.; Barth, S.; Camenisch, G.; Wenger, R.H.
Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation (2005), Blood, 105, 4613-4619.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.16.3.1	CuCl2	increase in enzyme mRNA due to transcriptional activation of enzyme genes promoter	Mus musculus

Application

EC Number	Application	Comment	Organism
1.16.3.1	medicine	both hypoxia and CuCl2 increase ceruloplasmin mRNA levels in hepatoma cells due to transcriptional induction of enzyme gene promoter	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.16.3.1	Mus musculus	-	hypoxic mice	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.16.3.1	liver	both hypoxia and CuCl2 increase ceruloplasmin mRNA levels in hepatoma cells due to transcriptional induction of enzyme gene promoter	Mus musculus	-

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Release 2023.1 (January 2023)