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Literature summary extracted from

  • Lambert, D.W.; Hooper, N.M.; Turner, A.J.
    Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system (2008), Biochem. Pharmacol., 75, 781-786.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.17.23 medicine ACE2 is a functional receptor for the causative agent of severe acute repiratory syndrome, the SARS coronavirus, ACE2 also plays a role in the development of liver fibrosis and subsequent cirrhosis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 (S,S)-2-[1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-inidazol-4-yl]-ethylamino]-4-methylpentanoic acid MLN-4760 Homo sapiens
3.4.17.23 DX600
-
 Homo sapiens
3.4.17.23 additional information not inhibited by captopri and lisinopril Homo sapiens
3.4.17.23 Pro-Phe
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.17.23 membrane transmembrane enzyme Mus musculus 16020
-
3.4.17.23 membrane transmembrane enzyme Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.17.23 Zn2+ dependent Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.17.23 27000
-
 SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens
-
-
-
3.4.17.23 Mus musculus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.17.23 angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine a transmembrane glycoprotein with an extracellular catalytic domain. ACE2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 colon
-
 Homo sapiens
-
3.4.17.23 heart
-
 Homo sapiens
-
3.4.17.23 kidney
-
 Mus musculus
-
3.4.17.23 kidney
-
 Homo sapiens
-
3.4.17.23 lung
-
 Homo sapiens
-
3.4.17.23 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 (des-Arg9)-bradykinin + H2O
-
 Homo sapiens ?
-
 ?
3.4.17.23 angiotensin I + H2O poor affinity Homo sapiens angiotensin-(1-9) + Leu
-
 ?
3.4.17.23 angiotensin II + H2O efficient cleavage Homo sapiens angiotensin-(1-7) + Phe
-
 ?
3.4.17.23 apelin-13 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Homo sapiens
3.4.17.23 ACE2 homologue
-
 Mus musculus
3.4.17.23 angiotensin converting enzyme 2 functions as a carboxypeptidase Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.17.23 0.000044
-
 (S,S)-2-[1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-inidazol-4-yl]-ethylamino]-4-methylpentanoic acid
-
 Homo sapiens