Literature summary extracted from

Lee, H.S.; Lee, T.H.; Yang, S.H.; Shin, H.J.; Shin, J.; Oh, K.B.
Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. (2007), Bioorg. Med. Chem. Lett., 17, 2483-2486.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
4.1.3.1	(1R,2R,6E)-8-(2,5-dihydroxyphenyl)-2-hydroxy-6-methyl-1-[[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl]oct-6-en-1-yl hydrogen sulfate	-	Pyricularia grisea
4.1.3.1	2-[(2E,7R,8R)-7,8-dihydroxy-3-methyl-9-[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]non-2-en-1-yl]benzene-1,4-diol	-	Pyricularia grisea
4.1.3.1	3-nitropropionate	-	Pyricularia grisea
4.1.3.1	sodium (2S)-5-furan-3-yl-2-[(1R)-1-hydroxy-2-[(1S,2R,4aR,8aR)-2-methyl-5-methylidenedecahydronaphthalen-1-yl]ethyl]pentyl sulfate	-	Pyricularia grisea

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.1.3.1	Pyricularia grisea	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.1.3.1	isocitrate	-	Pyricularia grisea	succinate + glyoxylate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
4.1.3.1	ICL	-	Pyricularia grisea

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
4.1.3.1	0.0126	-	-	Pyricularia grisea	(1R,2R,6E)-8-(2,5-dihydroxyphenyl)-2-hydroxy-6-methyl-1-[[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl]oct-6-en-1-yl hydrogen sulfate
4.1.3.1	0.015	-	-	Pyricularia grisea	2-[(2E,7R,8R)-7,8-dihydroxy-3-methyl-9-[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]non-2-en-1-yl]benzene-1,4-diol
4.1.3.1	0.0674	-	-	Pyricularia grisea	sodium (2S)-5-furan-3-yl-2-[(1R)-1-hydroxy-2-[(1S,2R,4aR,8aR)-2-methyl-5-methylidenedecahydronaphthalen-1-yl]ethyl]pentyl sulfate
4.1.3.1	0.0924	-	-	Pyricularia grisea	3-nitropropionate

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)