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Literature summary extracted from
- Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17 (2008), Curr. Alzheimer Res., 5, 187-201.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.B9 | phorbol myristate acetate ester | - |
Mus musculus |  |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.24.81 | molecular biology | Kuzbanian, the ADAM10 orthologue in Drosophila melanogaster plays an important role in axon guidance by building a complex with ephrinA2, which is cleaved off from the membrane in a moment of EphA3 receptor binding | Drosophila melanogaster |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.B9 | expressed in COS cells | Mus musculus |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.24.81 | additional information | in ADAM10 deficient mouse embryonic cells the constitutive release of soluble epidermal growth factor and also beta-cellulin is strongly reduced when compared with wild type controls and can be reintroduced by adding of wild type ADAM10. Overexpression of ADAM10 causes an increase in beta-cellulin shedding, whereas the overexpression of catalytically inactive ADAM10 decreases the beta-cellulin shedding | Mus musculus |
| 3.4.24.81 | additional information | the ADAM10 knockout mouse virtually represents a phenocopy of a presenilin 1/presenilin 2 double deficient mouse and thus features many traits attributable to defective Notch signalling | Mus musculus |
| 3.4.24.81 | additional information | the in vivo relevance of the processing of E-cadherin is supported by data from cell extracts from ADAM10 deficient mouse embryos at embryonic day 9.5, indicating that the generation is completely abolished in the knockout mice | Mus musculus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.B9 | Mus musculus | - |
- |
- |
| 3.4.24.81 | Drosophila melanogaster | - |
in Drosophila, the ADAM10 orthologue kuzbanian acts act as Notch sheddase | - |
| 3.4.24.81 | Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.B9 | ADAM10 + H2O | shedding of the ectodomain of ADAM10 | Mus musculus | ? | - |
? | |
| 3.4.24.B9 | amyloid precursor protein + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.B9 | beta-casein + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.B9 | Fibronectin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.B9 | Gelatin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.B9 | insulin B chain + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.24.B9 | pro-heparin-binding EGF-like growth factor + H2O | - |
Mus musculus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.B9 | ADAM 9 | - |
Mus musculus |
| 3.4.24.B9 | MDC9 | - |
Mus musculus |
| 3.4.24.B9 | meltrin gamma | - |
Mus musculus |
| 3.4.24.B9 | metalloprotease disintegrin 9 | - |
Mus musculus |
| 3.4.24.81 | kuzbanian | - |
Drosophila melanogaster |
| 3.4.24.81 | kuzbanian | - |
Mus musculus |
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