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Literature summary extracted from

  • Garabelli, P.J.; Modrall, J.G.; Penninger, J.M.; Ferrario, C.M.; Chappell, M.C.
    Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart (2008), Exp. Physiol., 93, 613-621.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.17.1 additional information in agiotensin-converting enzyme -/- mice the addition of the carboxypeptidase A inhibitor benzylsuccinate essentially abolishs the formation of Ang(1-9) and increases the levels of angiotensin I in cardiac membranes Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.1 benzylsuccinate
-
 Mus musculus
3.4.17.23 benzylsuccinate essentially abolishes the formation of Ang(1-9) by ACE2 Mus musculus
3.4.17.23 MLN-4760 total inhibition at 0.01 mM Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.17.23 membrane
-
 Mus musculus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.1 Mus musculus
-
-
-
3.4.17.23 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.1 heart
-
 Mus musculus
-
3.4.17.23 heart
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin I + H2O
-
 Mus musculus angiotensin-(1-9) + Leu
-
 ?
3.4.17.23 angiotensin II + H2O
-
 Mus musculus angiotensin-(1-7) + Phe
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.1 carboxypeptidase a
-
 Mus musculus
3.4.17.23 ACE2
-
 Mus musculus