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Literature summary extracted from

  • Molina, A.J.; Merino, G.; Prieto, J.G.; Real, R.; Mendoza, G.; Alvarez, A.I.
    Absorption and metabolism of albendazole after intestinal ischemia/reperfusion (2007), Eur. J. Pharm. Sci., 31, 16-24.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.32 0.0198
-
 albendazole
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.32 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.32 albendazole + NADPH + H+ + O2 Rattus norvegicus
-
 albendazole S-oxide + NADP+ + H2O
-
 ?
1.14.13.32 additional information Rattus norvegicus intestinal bioconversion of the anthelmintic drug albendazole into albendazole sulfoxide by two enzymatic systems, cytochrome P4503A and flavin-containing monooxygenases, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.32 Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.32 ileum
-
 Rattus norvegicus
-
1.14.13.32 intestine
-
 Rattus norvegicus
-
1.14.13.32 jejunum
-
 Rattus norvegicus
-
1.14.13.32 additional information in situ enzyme assays, histochemic analysis, overview Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.13.32 additional information
-
 in situ activity in the intestine Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.32 albendazole + NADPH + H+ + O2
-
 Rattus norvegicus albendazole S-oxide + NADP+ + H2O
-
 ?
1.14.13.32 additional information intestinal bioconversion of the anthelmintic drug albendazole into albendazole sulfoxide by two enzymatic systems, cytochrome P4503A and flavin-containing monooxygenases, overview Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.32 albendazol sulfoxidase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.32 FAD
-
 Rattus norvegicus
1.14.13.32 NADPH
-
 Rattus norvegicus