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Literature summary extracted from

  • Rodriguez, J.L.; Boukaba, A.; Sandoval, J.; Georgieva, E.I.; Latasa, M.U.; Garcia-Trevijano, E.R.; Serviddio, G.; Nakamura, T.; Avila, M.A.; Sastre, J.; Torres, L.; Mato, J.M.; Lopez-Rodas, G.
    Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells (2007), Int. J. Biochem. Cell Biol., 39, 842-850.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.5.1.6 E2F1 present continually in the MAT2A promoter during liver regeneration Rattus norvegicus
2.5.1.6 E2F3 present continually in the MAT2A promoter during liver regeneration Rattus norvegicus
2.5.1.6 E2F4 present continually in the MAT2A promoter during liver regeneration Rattus norvegicus
2.5.1.6 Sp1 binding of Sp1 to the MAT2A promoter is essential for the transcriptional up-regulation of the gene Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.6 Rattus norvegicus P18298
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.6 hepatocyte adult quiescent hepatocyte Rattus norvegicus
-
2.5.1.6 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.6 ATP + L-methionine + H2O
-
 Rattus norvegicus phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.6 MAT II isozyme Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.6 ATP
-
 Rattus norvegicus