EC Number | Application | Comment | Organism |
---|---|---|---|
1.13.12.5 | analysis | analysis of luciferase inhibitors by quantitative high-throughput screening and comparison of and structure-activity relationship using various luciferase-based detection reagents | Renilla reniformis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.13.12.5 | (2Z)-3-[(2-bromophenyl)amino]-1-pyridin-2-ylprop-2-en-1-one | - |
Renilla reniformis | |
1.13.12.5 | (2Z)-3-[[4-(dimethylamino)cyclohexa-1,5-dien-1-yl]amino]-1-phenylprop-2-en-1-one | - |
Renilla reniformis | |
1.13.12.5 | (3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1,3-dihydro-2H-indol-2-one | common name SU4312 | Renilla reniformis | |
1.13.12.5 | 2-(4-ethoxyphenyl)-4-[(4-methylpiperazin-1-yl)carbonyl]quinoline | - |
Renilla reniformis | |
1.13.12.5 | 2-(4-ethoxyphenyl)-4-[(4-pyridin-2-ylpiperazin-1-yl)carbonyl]quinoline | - |
Renilla reniformis | |
1.13.12.5 | 2-(4-methylphenyl)-4-[(4-pyrimidin-2-ylpiperazin-1-yl)carbonyl]quinoline | - |
Renilla reniformis | |
1.13.12.5 | 2-(5-naphthalen-2-yl-1,2,4-oxadiazol-3-yl)pyridine | - |
Renilla reniformis | |
1.13.12.5 | 2-hydroxy-N'-[(1E)-(2-hydroxyphenyl)methylidene]benzohydrazide | common name SCS | Renilla reniformis | |
1.13.12.5 | 2-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine | - |
Renilla reniformis | |
1.13.12.5 | 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-2-(4-ethoxyphenyl)quinoline | - |
Renilla reniformis | |
1.13.12.5 | 4-amino-6-[(E)-[4'-[(Z)-(8-amino-1-hydroxy-5,7-disulfonato-6,7-dihydronaphthalen-2-yl)diazenyl]-3-methylbiphenyl-4-yl]diazenyl]-5-hydroxy-2,3-dihydronaphthalene-1,3-disulfonate | common name Evans Blue | Renilla reniformis | |
1.13.12.5 | 4-[1-(1,3-benzothiazol-2-yl)-2-(4-methylpiperazin-1-yl)-2-oxoethyl]phenol | - |
Renilla reniformis | |
1.13.12.5 | 6-methyl-2-[(Z)-phenyldiazenyl]pyridin-3-ol | common name SIB1757 | Renilla reniformis | |
1.13.12.5 | ethyl 4-[[2-(4-ethoxyphenyl)quinolin-4-yl]carbonyl]piperazine-1-carboxylate | - |
Renilla reniformis | |
1.13.12.5 | additional information | structure-activity relationship of luciferase inhibitors determined by quantitative high-throughput screening. Comparison of effect on various luciferase-based detection reagents | Renilla reniformis | |
1.13.12.5 | N'-(3-chlorophenyl)-N-[(1Z)-(3-chlorophenyl)methylidene]imidoformamide | common name DCB | Renilla reniformis | |
1.13.12.7 | (2R)-2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]propanoic acid | common name indoprofen | Photinus pyralis | |
1.13.12.7 | (2Z)-1-(4-chlorophenyl)-3-(pyridin-2-ylamino)prop-2-en-1-one | - |
Photinus pyralis | |
1.13.12.7 | (2Z)-3-[(2-bromophenyl)amino]-1-pyridin-2-ylprop-2-en-1-one | - |
Photinus pyralis | |
1.13.12.7 | (2Z)-3-[(4-fluorophenyl)amino]-1-furan-2-ylprop-2-en-1-one | - |
Photinus pyralis | |
1.13.12.7 | (2Z)-3-[[4-(dimethylamino)cyclohexa-1,5-dien-1-yl]amino]-1-phenylprop-2-en-1-one | - |
Photinus pyralis | |
1.13.12.7 | (3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1,3-dihydro-2H-indol-2-one | common name SU4312 | Photinus pyralis | |
1.13.12.7 | 1-[3-(6-ethoxy-1,3-benzothiazol-2-yl)thiophen-2-yl]urea | - |
Photinus pyralis | |
1.13.12.7 | 2,4-dimethoxy-N-(5-methylpyridin-2-yl)benzamide | - |
Photinus pyralis | |
1.13.12.7 | 2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one | common name PD98059 | Photinus pyralis | |
1.13.12.7 | 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3(2H)-yl)-1-(4-methylphenyl)ethanone | common name pifithrin-alpha | Photinus pyralis | |
1.13.12.7 | 2-(4-ethoxyphenyl)-4-[(4-methylpiperazin-1-yl)carbonyl]quinoline | - |
Photinus pyralis | |
1.13.12.7 | 2-(4-ethoxyphenyl)-4-[(4-pyridin-2-ylpiperazin-1-yl)carbonyl]quinoline | - |
Photinus pyralis | |
1.13.12.7 | 2-(4-methylphenyl)-4-[(4-pyrimidin-2-ylpiperazin-1-yl)carbonyl]quinoline | - |
Photinus pyralis | |
1.13.12.7 | 2-(5-biphenyl-4-yl-1,2,4-oxadiazol-3-yl)pyridine | - |
Photinus pyralis | |
1.13.12.7 | 2-(5-naphthalen-2-yl-1,2,4-oxadiazol-3-yl)pyridine | - |
Photinus pyralis | |
1.13.12.7 | 2-hydroxy-N'-[(1E)-(2-hydroxyphenyl)methylidene]benzohydrazide | common name SCS | Photinus pyralis | |
1.13.12.7 | 2-methyl-6-(phenylethynyl)pyridine | common name MPEB | Photinus pyralis | |
1.13.12.7 | 2-methyl-6-[(Z)-2-phenylethenyl]pyridine | common name SIB1893 | Photinus pyralis | |
1.13.12.7 | 2-[5-(3,4-dichlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine | - |
Photinus pyralis | |
1.13.12.7 | 2-[5-(3-chloro-4-methylphenyl)-1,2,4-oxadiazol-3-yl]pyridine | - |
Photinus pyralis | |
1.13.12.7 | 2-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine | - |
Photinus pyralis | |
1.13.12.7 | 2-[5-(5-bromofuran-2-yl)-1,2,4-oxadiazol-3-yl]pyridine | - |
Photinus pyralis | |
1.13.12.7 | 3-(2-hydroxyphenyl)-1H-benzo[f]chromen-1-one | common name flavonoid | Photinus pyralis | |
1.13.12.7 | 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-2-(4-ethoxyphenyl)quinoline | - |
Photinus pyralis | |
1.13.12.7 | 4-amino-6-[(E)-[4'-[(Z)-(8-amino-1-hydroxy-5,7-disulfonato-6,7-dihydronaphthalen-2-yl)diazenyl]-3-methylbiphenyl-4-yl]diazenyl]-5-hydroxy-2,3-dihydronaphthalene-1,3-disulfonate | common name Evans Blue | Photinus pyralis | |
1.13.12.7 | 4-methoxy-N-[(4-methylpyridin-2-yl)carbamoyl]benzamide | - |
Photinus pyralis | |
1.13.12.7 | 4-[1-(1,3-benzothiazol-2-yl)-2-(4-methylpiperazin-1-yl)-2-oxoethyl]phenol | - |
Photinus pyralis | |
1.13.12.7 | 5-(2,4-dimethoxyphenyl)-3-phenyl-1,2,4-oxadiazole | - |
Photinus pyralis | |
1.13.12.7 | 5-(2-bromophenyl)-3-(4-methylphenyl)-1,2,4-oxadiazole | - |
Photinus pyralis | |
1.13.12.7 | 5-(2-chloro-4-methylphenyl)-3-phenyl-1,2,4-oxadiazole | - |
Photinus pyralis | |
1.13.12.7 | 5-methyl-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]thiophene-2-carboxamide | - |
Photinus pyralis | |
1.13.12.7 | 5-naphthalen-2-yl-3-phenyl-1,2,4-oxadiazole | - |
Photinus pyralis | |
1.13.12.7 | 6-methyl-2-[(Z)-phenyldiazenyl]pyridin-3-ol | common name SIB1757 | Photinus pyralis | |
1.13.12.7 | ethyl 4-[[2-(4-ethoxyphenyl)quinolin-4-yl]carbonyl]piperazine-1-carboxylate | - |
Photinus pyralis | |
1.13.12.7 | N'-(3-chlorophenyl)-N-[(1Z)-(3-chlorophenyl)methylidene]imidoformamide | common name DCB | Photinus pyralis | |
1.13.12.7 | N-(4-ethoxyphenyl)-2-methoxybenzamide | - |
Photinus pyralis | |
1.13.12.7 | N-(6-ethoxy-1,3-benzothiazol-2-yl)-2-methylfuran-3-carboxamide | - |
Photinus pyralis | |
1.13.12.7 | N-(6-methoxy-1,3-benzothiazol-2-yl)-2-methylfuran-3-carboxamide | - |
Photinus pyralis | |
1.13.12.7 | N-(6-methyl-1,3-benzothiazol-2-yl)thiophene-2-carboxamide | - |
Photinus pyralis | |
1.13.12.7 | N-[5-[(2,2-dimethylpropanoyl)amino]pyridin-2-yl]-3-hydroxybenzamide | - |
Photinus pyralis | |
1.13.12.7 | N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]thiophene-2-carboxamide | - |
Photinus pyralis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.13.12.5 | Renilla reniformis | - |
- |
- |
1.13.12.7 | Photinus pyralis | Q27758 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.12.5 | D-luciferin + O2 + ATP | - |
Renilla reniformis | oxidized D-luciferin + CO2 + H2O + AMP + diphosphate + hv | - |
? | |
1.13.12.7 | D-luciferin + O2 + ATP | - |
Photinus pyralis | oxidized D-luciferin + CO2 + H2O + AMP + diphosphate + hv | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.13.12.5 | firefly luciferase | - |
Renilla reniformis |
1.13.12.5 | Luc | - |
Renilla reniformis |
1.13.12.7 | firefly luciferase | - |
Photinus pyralis |
1.13.12.7 | Luc | - |
Photinus pyralis |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.13.12.5 | 0.01 | - |
- |
Renilla reniformis | 4-amino-6-[(E)-[4'-[(Z)-(8-amino-1-hydroxy-5,7-disulfonato-6,7-dihydronaphthalen-2-yl)diazenyl]-3-methylbiphenyl-4-yl]diazenyl]-5-hydroxy-2,3-dihydronaphthalene-1,3-disulfonate | |
1.13.12.5 | 0.011 | - |
- |
Renilla reniformis | (2Z)-3-[[4-(dimethylamino)cyclohexa-1,5-dien-1-yl]amino]-1-phenylprop-2-en-1-one | |
1.13.12.5 | 0.011 | - |
- |
Renilla reniformis | 2-(4-ethoxyphenyl)-4-[(4-pyridin-2-ylpiperazin-1-yl)carbonyl]quinoline | |
1.13.12.5 | 0.011 | - |
- |
Renilla reniformis | 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-2-(4-ethoxyphenyl)quinoline | |
1.13.12.5 | 0.011 | - |
pH 7.2, 22°C | Renilla reniformis | (2Z)-3-[[4-(dimethylamino)cyclohexa-1,5-dien-1-yl]amino]-1-phenylprop-2-en-1-one | |
1.13.12.5 | 0.011 | - |
pH 7.2, 22°C | Renilla reniformis | 2-(4-ethoxyphenyl)-4-[(4-pyridin-2-ylpiperazin-1-yl)carbonyl]quinoline | |
1.13.12.5 | 0.011 | - |
pH 7.2, 22°C | Renilla reniformis | 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-2-(4-ethoxyphenyl)quinoline | |
1.13.12.5 | 0.019 | - |
- |
Renilla reniformis | (3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1,3-dihydro-2H-indol-2-one | |
1.13.12.5 | 0.019 | - |
pH 7.2, 22°C | Renilla reniformis | (3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1,3-dihydro-2H-indol-2-one | |
1.13.12.5 | 0.02 | - |
- |
Renilla reniformis | 2-hydroxy-N'-[(1E)-(2-hydroxyphenyl)methylidene]benzohydrazide | |
1.13.12.5 | 0.02 | - |
- |
Renilla reniformis | ethyl 4-[[2-(4-ethoxyphenyl)quinolin-4-yl]carbonyl]piperazine-1-carboxylate | |
1.13.12.5 | 0.02 | - |
pH 7.2, 22°C | Renilla reniformis | 2-hydroxy-N'-[(1E)-(2-hydroxyphenyl)methylidene]benzohydrazide | |
1.13.12.5 | 0.02 | - |
pH 7.2, 22°C | Renilla reniformis | ethyl 4-[[2-(4-ethoxyphenyl)quinolin-4-yl]carbonyl]piperazine-1-carboxylate | |
1.13.12.5 | 0.0225 | - |
- |
Renilla reniformis | 4-[1-(1,3-benzothiazol-2-yl)-2-(4-methylpiperazin-1-yl)-2-oxoethyl]phenol | |
1.13.12.5 | 0.0225 | - |
pH 7.2, 22°C | Renilla reniformis | 4-[1-(1,3-benzothiazol-2-yl)-2-(4-methylpiperazin-1-yl)-2-oxoethyl]phenol | |
1.13.12.5 | 0.025 | - |
- |
Renilla reniformis | 2-(5-naphthalen-2-yl-1,2,4-oxadiazol-3-yl)pyridine | |
1.13.12.5 | 0.025 | - |
IC50 above 0.025 mM | Renilla reniformis | 2-(4-ethoxyphenyl)-4-[(4-methylpiperazin-1-yl)carbonyl]quinoline | |
1.13.12.5 | 0.025 | - |
IC50 above 0.025 mM | Renilla reniformis | 2-(4-methylphenyl)-4-[(4-pyrimidin-2-ylpiperazin-1-yl)carbonyl]quinoline | |
1.13.12.5 | 0.025 | - |
pH 7.2, 22°C | Renilla reniformis | 2-(5-naphthalen-2-yl-1,2,4-oxadiazol-3-yl)pyridine | |
1.13.12.5 | 0.036 | - |
- |
Renilla reniformis | 6-methyl-2-[(Z)-phenyldiazenyl]pyridin-3-ol | |
1.13.12.5 | 0.05 | - |
IC50 above 0.05 mM | Renilla reniformis | (2Z)-3-[(2-bromophenyl)amino]-1-pyridin-2-ylprop-2-en-1-one | |
1.13.12.5 | 0.05 | - |
IC50 above 0.05 mM | Renilla reniformis | 2-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine | |
1.13.12.5 | 0.05 | - |
IC50 above 0.05 mM | Renilla reniformis | N'-(3-chlorophenyl)-N-[(1Z)-(3-chlorophenyl)methylidene]imidoformamide | |
1.13.12.7 | 0.00005 | - |
- |
Photinus pyralis | 3-(2-hydroxyphenyl)-1H-benzo[f]chromen-1-one | |
1.13.12.7 | 0.00008 | - |
- |
Photinus pyralis | (2Z)-3-[(2-bromophenyl)amino]-1-pyridin-2-ylprop-2-en-1-one | |
1.13.12.7 | 0.00008 | - |
- |
Photinus pyralis | 2,4-dimethoxy-N-(5-methylpyridin-2-yl)benzamide | |
1.13.12.7 | 0.0001 | - |
- |
Photinus pyralis | 2-(5-biphenyl-4-yl-1,2,4-oxadiazol-3-yl)pyridine | |
1.13.12.7 | 0.0001 | - |
- |
Photinus pyralis | 2-(5-naphthalen-2-yl-1,2,4-oxadiazol-3-yl)pyridine | |
1.13.12.7 | 0.00015 | - |
- |
Photinus pyralis | 5-(2,4-dimethoxyphenyl)-3-phenyl-1,2,4-oxadiazole | |
1.13.12.7 | 0.00015 | - |
- |
Photinus pyralis | 5-(2-chloro-4-methylphenyl)-3-phenyl-1,2,4-oxadiazole | |
1.13.12.7 | 0.0002 | - |
- |
Photinus pyralis | (2R)-2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]propanoic acid | |
1.13.12.7 | 0.00021 | - |
- |
Photinus pyralis | (2Z)-3-[[4-(dimethylamino)cyclohexa-1,5-dien-1-yl]amino]-1-phenylprop-2-en-1-one | |
1.13.12.7 | 0.00022 | - |
- |
Photinus pyralis | 2-[5-(3-chloro-4-methylphenyl)-1,2,4-oxadiazol-3-yl]pyridine | |
1.13.12.7 | 0.0003 | - |
- |
Photinus pyralis | 4-[1-(1,3-benzothiazol-2-yl)-2-(4-methylpiperazin-1-yl)-2-oxoethyl]phenol | |
1.13.12.7 | 0.00032 | - |
- |
Photinus pyralis | 2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3(2H)-yl)-1-(4-methylphenyl)ethanone | |
1.13.12.7 | 0.00041 | - |
- |
Photinus pyralis | 2-(4-ethoxyphenyl)-4-[(4-pyridin-2-ylpiperazin-1-yl)carbonyl]quinoline | |
1.13.12.7 | 0.00041 | - |
- |
Photinus pyralis | 4-methoxy-N-[(4-methylpyridin-2-yl)carbamoyl]benzamide | |
1.13.12.7 | 0.00041 | - |
- |
Photinus pyralis | 5-naphthalen-2-yl-3-phenyl-1,2,4-oxadiazole | |
1.13.12.7 | 0.0005 | - |
- |
Photinus pyralis | 2-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine | |
1.13.12.7 | 0.0005 | - |
- |
Photinus pyralis | N-(6-methyl-1,3-benzothiazol-2-yl)thiophene-2-carboxamide | |
1.13.12.7 | 0.0006 | - |
- |
Photinus pyralis | 1-[3-(6-ethoxy-1,3-benzothiazol-2-yl)thiophen-2-yl]urea | |
1.13.12.7 | 0.0006 | - |
- |
Photinus pyralis | N-(4-ethoxyphenyl)-2-methoxybenzamide | |
1.13.12.7 | 0.00065 | - |
- |
Photinus pyralis | N-(6-ethoxy-1,3-benzothiazol-2-yl)-2-methylfuran-3-carboxamide | |
1.13.12.7 | 0.0007 | - |
- |
Photinus pyralis | 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-2-(4-ethoxyphenyl)quinoline | |
1.13.12.7 | 0.0007 | - |
- |
Photinus pyralis | N-[5-[(2,2-dimethylpropanoyl)amino]pyridin-2-yl]-3-hydroxybenzamide | |
1.13.12.7 | 0.0008 | - |
- |
Photinus pyralis | (3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1,3-dihydro-2H-indol-2-one | |
1.13.12.7 | 0.0008 | - |
- |
Photinus pyralis | 2-hydroxy-N'-[(1E)-(2-hydroxyphenyl)methylidene]benzohydrazide | |
1.13.12.7 | 0.00084 | - |
- |
Photinus pyralis | 2-[5-(3,4-dichlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine | |
1.13.12.7 | 0.0009 | - |
- |
Photinus pyralis | ethyl 4-[[2-(4-ethoxyphenyl)quinolin-4-yl]carbonyl]piperazine-1-carboxylate | |
1.13.12.7 | 0.001 | - |
- |
Photinus pyralis | (2Z)-3-[(4-fluorophenyl)amino]-1-furan-2-ylprop-2-en-1-one | |
1.13.12.7 | 0.001 | - |
- |
Photinus pyralis | 5-(2-bromophenyl)-3-(4-methylphenyl)-1,2,4-oxadiazole | |
1.13.12.7 | 0.0011 | - |
- |
Photinus pyralis | 5-methyl-N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]thiophene-2-carboxamide | |
1.13.12.7 | 0.0011 | - |
- |
Photinus pyralis | N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]thiophene-2-carboxamide | |
1.13.12.7 | 0.0012 | - |
- |
Photinus pyralis | N-(6-methoxy-1,3-benzothiazol-2-yl)-2-methylfuran-3-carboxamide | |
1.13.12.7 | 0.0013 | - |
- |
Photinus pyralis | 2-(4-ethoxyphenyl)-4-[(4-methylpiperazin-1-yl)carbonyl]quinoline | |
1.13.12.7 | 0.0017 | - |
- |
Photinus pyralis | 4-amino-6-[(E)-[4'-[(Z)-(8-amino-1-hydroxy-5,7-disulfonato-6,7-dihydronaphthalen-2-yl)diazenyl]-3-methylbiphenyl-4-yl]diazenyl]-5-hydroxy-2,3-dihydronaphthalene-1,3-disulfonate | |
1.13.12.7 | 0.002 | - |
- |
Photinus pyralis | (2Z)-1-(4-chlorophenyl)-3-(pyridin-2-ylamino)prop-2-en-1-one | |
1.13.12.7 | 0.0032 | - |
- |
Photinus pyralis | 2-[5-(5-bromofuran-2-yl)-1,2,4-oxadiazol-3-yl]pyridine | |
1.13.12.7 | 0.004 | - |
- |
Photinus pyralis | 2-(4-methylphenyl)-4-[(4-pyrimidin-2-ylpiperazin-1-yl)carbonyl]quinoline | |
1.13.12.7 | 0.0043 | - |
- |
Photinus pyralis | 2-methyl-6-[(Z)-2-phenylethenyl]pyridine | |
1.13.12.7 | 0.0045 | - |
- |
Photinus pyralis | 6-methyl-2-[(Z)-phenyldiazenyl]pyridin-3-ol | |
1.13.12.7 | 0.0045 | - |
- |
Photinus pyralis | N'-(3-chlorophenyl)-N-[(1Z)-(3-chlorophenyl)methylidene]imidoformamide | |
1.13.12.7 | 0.0047 | - |
- |
Photinus pyralis | 2-methyl-6-(phenylethynyl)pyridine | |
1.13.12.7 | 0.0062 | - |
- |
Photinus pyralis | 2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one |