EC Number | Application | Comment | Organism |
---|---|---|---|
7.1.1.2 | medicine | mitochondrial complex I plays an important role in modulating Toll-like receptor 4-mediated neutrophil activation. Metformin, as well as other agents that inhibit mitochondrial complex I, may be useful in the prevention or treatment of acute inflammatory processes in which activated neutrophils play a major role, such as acute lung injury | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
7.1.1.2 | metformin | inhibits complex I activity, associated with LPS-induced neutrophil activation. Metformin prevents LPS-induced acute lung injury | Mus musculus | |
7.1.1.2 | rotenone | inhibits complex I, which is associated with increased ROS generation, LPS-induced nuclear translocation of NF-kappaB and cytokine production in neutrophils. Rotenone pretreatment attenuates LPS-induced acute lung injury | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
7.1.1.2 | mitochondrion | - |
Mus musculus | 5739 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.1.1.2 | Mus musculus | - |
male C57BL/6 mice | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
7.1.1.2 | bone marrow | - |
Mus musculus | - |
7.1.1.2 | liver | - |
Mus musculus | - |
7.1.1.2 | lung | - |
Mus musculus | - |
7.1.1.2 | neutrophil | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.1.1.2 | NADH + coenzyme Q1 + H+ | - |
Mus musculus | NAD+ + reduced coenzyme Q1 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
7.1.1.2 | complex I | - |
Mus musculus |