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Literature summary extracted from

  • Rampal, R.; Luther, K.B.; Haltiwanger, R.S.
    Notch signaling in normal and disease States: possible therapies related to glycosylation (2007), Curr. Mol. Med., 7, 427-445.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.222 additional information fringe requires a properly folded EGF repeat modified by O-fucose for its enzymatic activity Drosophila melanogaster
2.4.1.222 additional information fringe requires a properly folded EGF repeat modified by O-fucose for its enzymatic activity Mammalia
2.4.1.222 additional information fringe requires a properly folded EGF repeat modified by O-fucose for its enzymatic activity Homo sapiens

Application

EC Number Application Comment Organism
2.4.1.222 medicine the Notch signaling pathway is involved in numerous developmental cascades in mammals, mutations in the pathway have been implicated in a variety of Human diseases, like CADASIL, spondylocostal dysostosis, alagille syndrome, cancer and multiple sclerosis Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.222
-
 Mammalia

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.222
-
 Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.222 Golgi apparatus
-
 Drosophila melanogaster 5794
-
2.4.1.222 Golgi apparatus
-
 Mammalia 5794
-
2.4.1.222 Golgi apparatus
-
 Homo sapiens 5794
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.222 Mn2+
-
 Drosophila melanogaster
2.4.1.222 Mn2+
-
 Mammalia
2.4.1.222 Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.222 additional information Drosophila melanogaster transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor ?
-
 ?
2.4.1.222 additional information Mammalia transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor ?
-
 ?
2.4.1.222 additional information Homo sapiens transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.222 Drosophila melanogaster
-
-
-
2.4.1.222 Homo sapiens
-
-
-
2.4.1.222 Mammalia
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.222
-
 Mammalia

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.222 eye
-
 Drosophila melanogaster
-
2.4.1.222 leg
-
 Drosophila melanogaster
-
2.4.1.222 oocyte
-
 Drosophila melanogaster
-
2.4.1.222 wing
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.222 additional information transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor Drosophila melanogaster ?
-
 ?
2.4.1.222 additional information transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor Mammalia ?
-
 ?
2.4.1.222 additional information transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.222 beta-1,3-N-acetylglucosaminyltransferase
-
 Drosophila melanogaster
2.4.1.222 beta-1,3-N-acetylglucosaminyltransferase
-
 Mammalia
2.4.1.222 beta-1,3-N-acetylglucosaminyltransferase
-
 Homo sapiens
2.4.1.222 Dfng
-
 Drosophila melanogaster