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Literature summary extracted from

  • Ronnebaum, S.M.; Joseph, J.W.; Ilkayeva, O.; Burgess, S.C.; Lu, D.; Becker, T.C.; Sherry, A.D.; Newgard, C.B.
    Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism (2008), J. Biol. Chem., 283, 14248-14256.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
6.4.1.2 medicine possible use of ACC inhibitors for diabetes therapy Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
6.4.1.2 additional information downregulation of the enzyme by siRNA transfected into the INS-1-derived cell line 832/13 affects insulin secretion, the enzyme activity in 832/13 cells and islets is reduced by 46-80% compared to the untreated cells, and glucose-stimulated insulin secretion is reduced by 70% in 832/13 cells and by 33% in islets, phenotypes, overview Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.2 5-(tetradecyloxy)-2-furoic acid an ACC1 inhibitor e.g. in beta cells Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.4.1.2 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3- Rattus norvegicus
-
 ADP + phosphate + malonyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.2 Rattus norvegicus P11497
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.4.1.2 gastrocnemius
-
 Rattus norvegicus
-
6.4.1.2 liver
-
 Rattus norvegicus
-
6.4.1.2 additional information ACC1 and ACC2 tissue expression pattern, overview Rattus norvegicus
-
6.4.1.2 pancreatic beta cell
-
 Rattus norvegicus
-
6.4.1.2 pancreatic islet
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.4.1.2 ACC1
-
 Rattus norvegicus
6.4.1.2 acetyl-CoA carboxylase 1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.2 ATP
-
 Rattus norvegicus