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Literature summary extracted from

  • Canfield, L.M.
    Vitamin K-dependent oxygenase/carboxylase; differential inactivation by sulfhydryl reagents (1987), Biochem. Biophys. Res. Commun., 148, 184-191.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.90 iodoacetic acid poor inhibitor Rattus norvegicus
4.1.1.90 N-ethylmaleimide preincubation with vitamin K hydroquinone prevents NEM inhibition of epoxide formation but not of carboxylation Rattus norvegicus
4.1.1.90 p-hydroxymercuribenzoate 1 mM, more than 90% inhibition, inhibition is reversed by dithiothreitol Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.90 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.90 Rattus norvegicus O88496
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.90
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.90 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.90 additional information separate active sites are required to support vitamin K-dependent epoxide formation and carboxylation. The binding site for vitamin K oxygenase contains an active thiol group Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.90 glutamate carboxylase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.90 vitamin K
-
 Rattus norvegicus