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Literature summary extracted from

  • Abed, Y.; Baz, M.; Boivin, G.
    A novel neuraminidase deletion mutation conferring resistance to oseltamivir in clinical influenza A/H3N2 virus (2009), J. Infect. Dis., 199, 180-183.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.2.1.18 N146K/A272V/Del245-248 revertant constructed from mutant N146K/S219T/A272V/Del245-248 for analysis of resistance to oseltamivir influenza A virus
3.2.1.18 N146K/S219T/A272V revertant constructed from mutant N146K/S219T/A272V/Del245-248 for analysis of resistance to oseltamivir influenza A virus
3.2.1.18 N146K/S219T/A272V/Del245-248 mutant isolated from an oseltamivir-resistant virus from an immunocompromised child. The deletion is the sole change responsible for resistance influenza A virus
3.2.1.18 N146K/S219T/Del245-248 revertant constructed from mutant N146K/S219T/A272V/Del245-248 for analysis of resistance to oseltamivir influenza A virus
3.2.1.18 S219T/A272V/Del245-248 revertant constructed from mutant N146K/S219T/A272V/Del245-248 for analysis of resistance to oseltamivir influenza A virus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.18 oseltamivir
-
 influenza A virus
3.2.1.18 peramivir
-
 influenza A virus
3.2.1.18 zanamivir
-
 influenza A virus

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.18 influenza A virus
-
 type H3N2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.18 2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
-
 influenza A virus 4-methylumbelliferol + alpha-D-N-acetylneuraminic acid
-
 ?