EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.1.37 | overexpression of Dnmt3a and Dnmt3b | Drosophila melanogaster |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.1.1.37 | additional information | enzyme overexpression does not cause an altered phenotype | Drosophila melanogaster |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.1.1.37 | nucleus | - |
Drosophila melanogaster | 5634 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.37 | DNA + S-adenosyl-L-methionine | Drosophila melanogaster | the enzyme has distinct target sequences but no preferred methylation sites of promoters or other regulatory elements | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.37 | Drosophila melanogaster | - |
isozymes Dnmt3a and Dnmt3b | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.37 | germ cell | male | Drosophila melanogaster | - |
2.1.1.37 | spermatid | - |
Drosophila melanogaster | - |
2.1.1.37 | spermatocyte | primary | Drosophila melanogaster | - |
2.1.1.37 | testis | - |
Drosophila melanogaster | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.37 | DNA + S-adenosyl-L-methionine | the enzyme has distinct target sequences but no preferred methylation sites of promoters or other regulatory elements | Drosophila melanogaster | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
2.1.1.37 | DNA + S-adenosyl-L-methionine | substrate is genomic DNA of Drosophila melanogaster | Drosophila melanogaster | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.37 | DNA (cytosine-5)-methyltransferase 3A | - |
Drosophila melanogaster |
2.1.1.37 | DNA (cytosine-5)-methyltransferase 3B | - |
Drosophila melanogaster |
2.1.1.37 | Dnmt3a | - |
Drosophila melanogaster |
2.1.1.37 | DNMT3B | - |
Drosophila melanogaster |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.1.1.37 | 37 | - |
assay at | Drosophila melanogaster |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.1.1.37 | 7.5 | - |
assay at | Drosophila melanogaster |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.37 | S-adenosyl-L-methionine | - |
Drosophila melanogaster |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.37 | physiological function | the DNA methylation by the enzyme has no regulatory function for gene expression in Drosophile melnogaster | Drosophila melanogaster |