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Literature summary extracted from

  • Kakugawa, S.; Shimojima, M.; Neumann, G.; Goto, H.; Kawaoka, Y.
    RuvB-like protein 2 is a suppressor of influenza A virus polymerases (2009), J. Virol., 83, 6429-6434.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.48 additional information inhibition of the assembly of the viral nucleoprotein, by RuvB-like protein 2, RBL2, and subsequent inhibition of the formation of the viral ribonucleoprotein complex inhibits viral RNA replication, overview influenza A virus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.48 additional information influenza A virus the RNA polymerase complex consists of three subunits, PB1, PB2, and PA. These polymerase subunits and nucleoprotein, together with the viral RNA, form the viral ribonucleoprotein complex, which is the minimum component for viral RNA replication and transcription ?
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Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 influenza A virus
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 belongs to the Orthomyxoviridae family
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 additional information the RNA polymerase complex consists of three subunits, PB1, PB2, and PA. These polymerase subunits and nucleoprotein, together with the viral RNA, form the viral ribonucleoprotein complex, which is the minimum component for viral RNA replication and transcription influenza A virus ?
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 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.48 heterotrimer the RNA polymerase complex consists of three subunits, PB1, PB2, and PA. These polymerase subunits and nucleoprotein, together with the viral RNA, form the viral ribonucleoprotein complex, which is the minimum component for viral RNA replication and transcription influenza A virus