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Literature summary extracted from

  • Phalke, S.; Nickel, O.; Walluscheck, D.; Hortig, F.; Onorati, M.C.; Reuter, G.
    Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2 (2009), Nat. Genet., 41, 696-702.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.37 DNMT2 controls retrotransposon silencing and 2R and 3R telomere integrity in somatic cells, overview Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.37 additional information generation of a series of null mutations by remobilization of the EP(2)GE15695 element inserted 108 bp upstream of the Dnmt2 gene. EP(2)GE15695 does not affect the Dnmt2 gene. Dnmt2 null strains show stable loss of the subtelomeric clusters of defective Invader4 elements, phenotype, overview Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.37 DNA + S-adenosyl-L-methionine Drosophila melanogaster
-
 DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.37 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.37 embryo early embryogenesis Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.37 DNA + S-adenosyl-L-methionine
-
 Drosophila melanogaster DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.37 cytosine-5 methyltransferase
-
 Drosophila melanogaster
2.1.1.37 Dnmt2
-
 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.37 S-adenosyl-L-methionine
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.1.1.37 physiological function DNMT2 controls retrotransposon silencing and telomere integrity in somatic cells, significant DNMT2-dependent DNA methylation occurs during early embryogenesis, overview Drosophila melanogaster