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Literature summary extracted from

  • Han, S.X.; He, G.M.; Wang, T.; Chen, L.; Ning, Y.Y.; Luo, F.; An, J.; Yang, T.; Dong, J.J.; Liao, Z.L.; Xu, D.; Wen, F.Q.
    Losartan attenuates chronic cigarette smoke exposure-induced pulmonary arterial hypertension in rats: possible involvement of angiotensin-converting enzyme-2 (2010), Toxicol. Appl. Pharmacol., 245, 100-107.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.17.23 losartan a specific angiotensin II receptor antagonist, is a well-known antihypertensive drug with a potential role in positively regulating ACE2 in the lung Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 DX600
-
 Rattus norvegicus
3.4.17.23 additional information chronic cigarette smoke administration causes an reduction in ACE2 activity and increases angiotensin II levels in the lung Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.23 angiotensin II + H2O Rattus norvegicus high levels of angiotensin II induces pulmonary arterial hypertension angiotensin(1-7) + L-Phe
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 cell culture
-
 Rattus norvegicus
-
3.4.17.23 lung
-
 Rattus norvegicus
-
3.4.17.23 pulmonary artery smooth muscle cell primary cell culture Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin II + H2O
-
 Rattus norvegicus angiotensin(1-7) + L-Phe
-
 ?
3.4.17.23 angiotensin II + H2O high levels of angiotensin II induces pulmonary arterial hypertension Rattus norvegicus angiotensin(1-7) + L-Phe
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Rattus norvegicus
3.4.17.23 angiotensin-converting enzyme-2
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.4.17.23 physiological function ACE2 is a regulator of the renin-angiotensin system,. Losartan, a specific angiotensin II receptor antagonist, is a well-known antihypertensive drug with a potential role in regulating ACE2 Rattus norvegicus