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Literature summary extracted from
- Inhibition of aldose reductase and xylose-induced lens opacity by puerariafuran from the roots of Pueraria lobata (2010), Biol. Pharm. Bull., 33, 1605-1609.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.21 | puerariafuran | a 2-arylbenzofuran from Pueraria lobata, collected in Kyonggi-do, Seongnam, Kyungwon University, Korea. Xylose-induced opacity of lenses is significantly improved when treated with puerariafuran | Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.21 | DL-glyceraldehyde + NADPH + H+ | Rattus norvegicus | - |
DL-glycerol + NADP+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.21 | Rattus norvegicus | - |
8-week-old Sprague-Dawley rats | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.21 | lens | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.21 | DL-glyceraldehyde + NADPH + H+ | - |
Rattus norvegicus | DL-glycerol + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.21 | aldose reductase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.21 | 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.21 | 7 | - |
assay at | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.21 | NADPH | - |
Rattus norvegicus | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.21 | 0.0223 | - |
pH 7.0, 37°C | Rattus norvegicus | puerariafuran | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.1.1.21 | physiological function | high sugar levels found in diabetic cataract cause the opacification of lenses by osmotic changes induced via the aldose reductase-mediated polyol pathway | Rattus norvegicus |
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Release 2023.1 (January 2023)
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