EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.21 | (2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one | - |
Homo sapiens | |
1.1.1.21 | (2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one | - |
Rattus norvegicus | |
1.1.1.21 | 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one | a gamma,gamma-dimethylallyl type prenylated isoflavonoid | Homo sapiens | |
1.1.1.21 | 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one | a gamma,gamma-dimethylallyl type prenylated isoflavonoid | Rattus norvegicus | |
1.1.1.21 | 3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one | a gamma,gamma-dimethylallyl type prenylated isoflavonoid | Homo sapiens | |
1.1.1.21 | 3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one | a gamma,gamma-dimethylallyl type prenylated isoflavonoid | Rattus norvegicus | |
1.1.1.21 | 4-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol | a gamma,gamma-dimethylallyl type prenylated isoflavonoid | Homo sapiens | |
1.1.1.21 | 4-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol | a gamma,gamma-dimethylallyl type prenylated isoflavonoid | Rattus norvegicus | |
1.1.1.21 | 4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol | a gamma,gamma-dimethylallyl type prenylated isoflavonoid | Homo sapiens | |
1.1.1.21 | 4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol | a gamma,gamma-dimethylallyl type prenylated isoflavonoid | Rattus norvegicus | |
1.1.1.21 | epalrestat | - |
Homo sapiens | |
1.1.1.21 | epalrestat | - |
Rattus norvegicus | |
1.1.1.21 | isoliquiritigenin | - |
Homo sapiens | |
1.1.1.21 | isoliquiritigenin | - |
Rattus norvegicus | |
1.1.1.21 | liquiritigenin | - |
Homo sapiens | |
1.1.1.21 | liquiritigenin | - |
Rattus norvegicus | |
1.1.1.21 | additional information | identification of inhibitory compounds from Glycyrrhiza uralensis, overview | Homo sapiens | |
1.1.1.21 | additional information | identification of inhibitory compounds from Glycyrrhiza uralensis, overview. Inhibitory effect of the compounds on the sorbitol accumulation in rat lenses incubated with high glucose | Rattus norvegicus | |
1.1.1.21 | Myricitrin | - |
Homo sapiens | |
1.1.1.21 | Myricitrin | - |
Rattus norvegicus | |
1.1.1.21 | quercetin | - |
Homo sapiens | |
1.1.1.21 | quercetin | - |
Rattus norvegicus | |
1.1.1.21 | quercitrin | - |
Homo sapiens | |
1.1.1.21 | quercitrin | - |
Rattus norvegicus | |
1.1.1.21 | semilicoisoflavone B | contains a gamma,gamma-dimethylchromene ring on the aromatic ring | Homo sapiens | |
1.1.1.21 | semilicoisoflavone B | contains a gamma,gamma-dimethylchromene ring on the aromatic ring | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.21 | DL-glyceraldehyde + NADPH + H+ | Homo sapiens | - |
DL-glycerol + NADP+ | - |
? | |
1.1.1.21 | DL-glyceraldehyde + NADPH + H+ | Rattus norvegicus | - |
DL-glycerol + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.21 | Homo sapiens | - |
- |
- |
1.1.1.21 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.21 | commercial preparation | recombinant enzyme | Homo sapiens | - |
1.1.1.21 | lens | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.21 | DL-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | DL-glycerol + NADP+ | - |
? | |
1.1.1.21 | DL-glyceraldehyde + NADPH + H+ | - |
Rattus norvegicus | DL-glycerol + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.21 | aldose reductase | - |
Homo sapiens |
1.1.1.21 | aldose reductase | - |
Rattus norvegicus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.1.1.21 | 37 | - |
assay at | Homo sapiens |
1.1.1.21 | 37 | - |
assay at | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.1.1.21 | 6.2 | - |
assay at | Homo sapiens |
1.1.1.21 | 7 | - |
assay at | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.21 | NADPH | - |
Homo sapiens | |
1.1.1.21 | NADPH | - |
Rattus norvegicus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.1.1.21 | 0.0018 | - |
pH 7.0, 37°C | Rattus norvegicus | semilicoisoflavone B | |
1.1.1.21 | 0.002 | - |
pH 7.0, 37°C | Rattus norvegicus | liquiritigenin | |
1.1.1.21 | 0.0025 | - |
pH 7.0, 37°C | Rattus norvegicus | quercetin | |
1.1.1.21 | 0.0034 | - |
pH 7.0, 37°C | Rattus norvegicus | isoliquiritigenin | |
1.1.1.21 | 0.0106 | - |
pH 6.2, 37°C | Homo sapiens | semilicoisoflavone B | |
1.1.1.21 | 0.0127 | - |
pH 7.0, 37°C | Homo sapiens | quercetin | |
1.1.1.21 | 0.0219 | - |
pH 7.0, 37°C | Homo sapiens | liquiritigenin | |
1.1.1.21 | 0.0275 | - |
pH 7.0, 37°C | Homo sapiens | isoliquiritigenin | |
1.1.1.21 | 0.0285 | - |
pH 7.0, 37°C | Rattus norvegicus | 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one | |
1.1.1.21 | 0.0427 | - |
pH 7.0, 37°C | Rattus norvegicus | 4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol | |
1.1.1.21 | 0.0624 | - |
pH 7.0, 37°C | Rattus norvegicus | 4-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol | |
1.1.1.21 | 0.0765 | - |
pH 7.0, 37°C | Homo sapiens | 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one | |
1.1.1.21 | 0.0963 | - |
pH 7.0, 37°C | Rattus norvegicus | (2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one | |
1.1.1.21 | 0.0995 | - |
pH 7.0, 37°C | Rattus norvegicus | 3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one | |
1.1.1.21 | 0.1306 | - |
pH 7.0, 37°C | Homo sapiens | 4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol | |
1.1.1.21 | 0.1762 | - |
pH 7.0, 37°C | Homo sapiens | 4-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol | |
1.1.1.21 | 0.2572 | - |
pH 7.0, 37°C | Homo sapiens | (2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one | |
1.1.1.21 | 0.2808 | - |
pH 7.0, 37°C | Homo sapiens | 3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one |