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Literature summary extracted from

  • Liu, H.; Reynolds, K.A.
    Precursor supply for polyketide biosynthesis: the role of crotonyl-CoA reductase (2001), Metab. Eng., 3, 40-48.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.86 Streptomyces virginiae
-
 strain C730.1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.86 crotonyl-CoA + NADPH + H+
-
 Streptomyces virginiae butyryl-CoA + NADP+
-
 ir

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.86 NADPH
-
 Streptomyces virginiae

Expression

EC Number Organism Comment Expression
1.3.1.86 Streptomyces virginiae the addition of 1.0 g/l L-lysine induces expression of the ccr gene in Streptomyces cinnamonensis strain C730.1 in chemically defined medium containing mainly D-glucose (12 g/l), L-tyrosine (3.3 g/l), and either L-valine (6.7 g/l) or L-leucine (7.5 g/l) as carbon and nitrogen sources up

General Information

EC Number General Information Comment Organism
1.3.1.86 physiological function CCR provides butyryl-CoA precursor for monensin A biosynthesis Streptomyces virginiae