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Literature summary extracted from

  • Xu, Z.; Yang, H.; Zhou, M.; Feng, Y.; Jia, W.
    Inhibitory effect of total lignan from fructus Arctii on aldose reductase (2010), Phytother. Res., 24, 472-473.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 epalrestat
-
 Rattus norvegicus
1.1.1.21 additional information inhibitory effect of total lignan from fructus Arctii on aldose reductase, ethanolic extract from dry ripe fruits of Arctium lappa Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.21 DL-glyceraldehyde + NADPH + H+ Rattus norvegicus
-
 DL-glycerol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 lens
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 DL-glyceraldehyde + NADPH + H+
-
 Rattus norvegicus DL-glycerol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 aldose reductase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.21 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.21 6.2
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.21 NADPH
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.1.1.21 metabolism aldose reductase is the key enzyme in the polyol pathway Rattus norvegicus