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Literature summary extracted from
- Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria (2010), Plant Cell, 22, 1549-1563.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.3.8.4 | gene ivdh, expression analysis and metabolic profiling | Arabidopsis thaliana |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.3.8.4 | additional information | construction of T-DNA mutant line GK756G02, an enzyme-deficient mutant with full-length ORFs including stop codons of IVDH, phenotype, overview | Arabidopsis thaliana |
| 1.5.5.1 | additional information | identification of mutants of the ETF/ETFQO complex | Arabidopsis thaliana |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.99.39 | mitochondrion | - |
Arabidopsis thaliana | 5739 | - |
| 1.3.8.4 | mitochondrion | - |
Arabidopsis thaliana | 5739 | - |
| 1.5.5.1 | mitochondrion | - |
Arabidopsis thaliana | 5739 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.99.39 | (R)-2-hydroxyglutarate + acceptor | Arabidopsis thaliana | - |
2-oxoglutarate + reduced acceptor | - |
? |  |
| 1.5.5.1 | reduced electron-transferring flavoprotein + ubiquinone | Arabidopsis thaliana | - |
electron-transferring flavoprotein + ubiquinol | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.99.39 | Arabidopsis thaliana | - |
ecotype Col-0 | - |
| 1.3.8.4 | Arabidopsis thaliana | Q9SWG0 | gene ivdh | - |
| 1.3.8.4 | Arabidopsis thaliana Col ecotype | Q9SWG0 | gene ivdh | - |
| 1.5.5.1 | Arabidopsis thaliana | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.99.39 | leaf | - |
Arabidopsis thaliana | - |
| 1.3.8.4 | leaf | - |
Arabidopsis thaliana | - |
| 1.5.5.1 | leaf | - |
Arabidopsis thaliana | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.99.39 | (R)-2-hydroxyglutarate + acceptor | - |
Arabidopsis thaliana | 2-oxoglutarate + reduced acceptor | - |
? | |
| 1.5.5.1 | reduced electron-transferring flavoprotein + ubiquinone | - |
Arabidopsis thaliana | electron-transferring flavoprotein + ubiquinol | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.99.39 | 2-hydroxyglutarate dehydrogenase | - |
Arabidopsis thaliana |
| 1.1.99.39 | D2HGDH | - |
Arabidopsis thaliana |
| 1.3.8.4 | IVDH | - |
Arabidopsis thaliana |
| 1.5.5.1 | electron-transfer flavoprotein:ubiquinone oxidoreductase | - |
Arabidopsis thaliana |
| 1.5.5.1 | ETFQO | - |
Arabidopsis thaliana |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.1.99.2 | metabolism | 2-hydroxyglutarate dehydrogenase is involved exclusively in lysine degradation. 2-hydroxyglutarate dehydrogenase act as electron donors to the ubiquinol pool via an electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase-mediated route | Arabidopsis thaliana |
| 1.3.8.4 | additional information | responses of Arabidopsis thaliana mutants deficient in the expression of isovaleryl-CoA dehydrogenase and 2-hydroxyglutarate dehydrogenase to extended darkness and other environmental stresses, phenotype, overview. Isovaleryl-CoA dehydrogenase is the more critical for alternative respiration. Both isovaleryl-CoA dehydrogenase and 2-hydroxyglutarate dehydrogenase act as electron donors to the ubiquinol pool via an electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase-mediated route | Arabidopsis thaliana |
| 1.3.8.4 | physiological function | involvement of ivdh in phytol degradation during dark-Induced starvation | Arabidopsis thaliana |
| 1.5.5.1 | malfunction | evaluations of the mutant phenotypes following carbon starvation induced by extended darkness identify similarities to those exhibited by mutants of the ETF/ETFQO complex, metabolic profiling, overview | Arabidopsis thaliana |
| 1.5.5.1 | metabolism | both isovaleryl-CoA dehydrogenase and 2-hydroxyglutarate dehydrogenase act as electron donors to the ubiquinol pool via an ETF/ETFQO-mediated route, overview. The ETF/ETFQO system can be regarded as a branch of the electron transport system with multiple input sites from seven acyl-CoA dehydrogenases and two N-methyl dehydrogenases, namely, isovaleryl-CoA dehydrogenase and 2-methyl branched-chain acyl-CoA dehydrogenase, as well as glutaryl-CoA dehydrogenase and sarcosine and dimethylglycine dehydrogenases | Arabidopsis thaliana |
| 1.5.5.1 | physiological function | the functional electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase (ETF/ETFQO) complex supports respiration during carbon starvation. The enzyme is involved in the process of dark-induced senescence | Arabidopsis thaliana |
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