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Literature summary extracted from

  • Stassi, D.L.; Kakavas, S.J.; Reynolds, K.A.; Gunawardana, G.; Swanson, S.; Zeidner, D.; Jackson, M.; Liu, H.; Buko, A.; Katz, L.
    Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering (1998), Proc. Natl. Acad. Sci. USA, 95, 7305-7309.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.86 expressed in Streptomyces erythraea strain EAT4 Streptomyces collinus

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.86 Streptomyces collinus
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.86 0.0008
-
 native enzyme, pH and temperature not specified in the publication Streptomyces collinus
1.3.1.86 0.0156
-
 recombinant enzyme, pH and temperature not specified in the publication Streptomyces collinus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.86 crotonyl-CoA + NADPH + H+
-
 Streptomyces collinus butyryl-CoA + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.86 CCR
-
 Streptomyces collinus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.86 NADPH
-
 Streptomyces collinus

General Information

EC Number General Information Comment Organism
1.3.1.86 physiological function in streptomycetes, Ccr catalyzes the last step in the reductive biosynthesis of butyryl-CoA from two molecules of acetyl-CoA Streptomyces collinus