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Literature summary extracted from

  • Krossøy, C.; Lock, E.; Ørnsrud, R.
    Vitamin K-dependent gamma-glutamylcarboxylase in Atlantic salmon (Salmo salar L.) (2010), Fish Physiol. Biochem., 36, 627-635.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.90 FLEEL the enzyme activity increases with increasing FLEEL peptide concentration up to 1.2 mM Salmo salar

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.90 FLEEL high FLEEL peptide substrate concentrations (from 1.2 up to 12 mM) inhibit GGCX activity Salmo salar

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.90 microsome
-
 Salmo salar
-
-

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.90 Salmo salar
-
 Atlantic salmon
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.90 bone
-
 Salmo salar
-
4.1.1.90 eye
-
 Salmo salar
-
4.1.1.90 heart
-
 Salmo salar
-
4.1.1.90 kidney
-
 Salmo salar
-
4.1.1.90 liver relatively high GGCX activity compared to other tissues Salmo salar
-
4.1.1.90 muscle
-
 Salmo salar
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.90 L-glutamate + CO2 + O2 + vitamin K hydroquinone
-
 Salmo salar gamma-carboxy L-glutamate + vitamin K epoxide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.90 GGCX
-
 Salmo salar
4.1.1.90 vitamin K-dependent gamma-glutamylcarboxylase
-
 Salmo salar

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.90 additional information menadione does not work as a cofactor for gamma-glutamylcarboxylase Salmo salar
4.1.1.90 vitamin K the enzyme requires vitamin K as a cofactor for its post-translational modification of glutamic acid residues to gamma-carboxyglutamic acid residues Salmo salar