EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.2.1.18 | influenza A virus | - |
avian influenzy virus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.2.1.18 | additional information | substrate specificity of the viral enzyme with sialic acid, methyl 3'-sialyllactoside, methyl 6'-sialyllactoside, ligand conformations, enzyme-ligand interactions, and loop flexibility, analyzed by molecular docking and molecular dynamics simulations, and molecular modeling, overview. Methyl 3'-sialyllactoside has only weak interactions with the 150-loop, whereas the enzyme N1-methyl 6'-sialyllactoside complex shows strong interactions. The avian neuraminidase N1 preferentially cleaves sialic acid from alpha-(2-3)-Gal glycoconjugates over alpha-(2-6)-Gal, also due to the altered flexibility of loops in and around the active site | influenza A virus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.2.1.18 | neuraminidase | - |
influenza A virus |