Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Pye, V.E.; Christensen, C.E.; Dyer, J.H.; Arent, S.; Henriksen, A.
    Peroxisomal plant 3-ketoacyl-CoA thiolase structure and activity are regulated by a sensitive redox switch (2010), J. Biol. Chem., 285, 24078-24088.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.16 to 1.5 A resolution. The dimeric structure exhibits a typical thiolase-like fold. Dimer formation and active site conformation appear in an open, active, reduced state Arabidopsis thaliana
2.3.1.16 to 1.8 A resolution. The dimeric structure exhibits a typical thiolase-like fold. Dimer formation and active site conformation appear in an open, active, reduced state Helianthus annuus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.16 cystamine 10 mM, inactivation with half-life of 0.6 h Arabidopsis thaliana
2.3.1.16 additional information in presence of 20 mM cysteamine, full activity is maintained for more than 12 h Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.16 peroxisome
-
 Arabidopsis thaliana 5777
-
2.3.1.16 peroxisome
-
 Helianthus annuus 5777
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.16 Arabidopsis thaliana Q56WD9
-
-
2.3.1.16 Helianthus annuus Q6W6X6
-
-

Storage Stability

EC Number Storage Stability Organism
2.3.1.16 in the absence of both cystamine and cysteamine isoform KAT2 spontaneously inactivates with a half-life Arabidopsis thaliana
2.3.1.16 of 2.6 h Arabidopsis thaliana

Subunits

EC Number Subunits Comment Organism
2.3.1.16 More enzyme interacts with the multifunctional protein that is responsible for the preceding two steps in beta-oxidation, which would allow a route for substrate channeling Arabidopsis thaliana
2.3.1.16 More enzyme interacts with the multifunctional protein that is responsible for the preceding two steps in beta-oxidation, which would allow a route for substrate channeling Helianthus annuus

Synonyms

EC Number Synonyms Comment Organism
2.3.1.16 KAT2
-
 Arabidopsis thaliana
2.3.1.16 KAT2
-
 Helianthus annuus