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Literature summary extracted from

  • Satpati, P.; Clavaguera, C.; Ohanessian, G.; Simonson, T.
    Free energy simulations of a GTPase: GTP and GDP binding to archaeal initiation factor 2 (2011), J. Phys. Chem. B, 115, 6749-6763.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.6.5.3 analysis of crystal structures of ON and OFF aIF2 at resolution of 3.0 and 2.15 A Saccharolobus solfataricus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.5.3 additional information
-
 additional information substrate and product binding kinetics and thermodynamics with ON and OFF aIF2 , overview Saccharolobus solfataricus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.5.3 Mg2+ required Saccharolobus solfataricus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.5.3 GTP + H2O Saccharolobus solfataricus
-
 GDP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.5.3 Saccharolobus solfataricus Q980A5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.5.3 GTP + H2O
-
 Saccharolobus solfataricus GDP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.5.3 aIF2
-
 Saccharolobus solfataricus
3.6.5.3 archaeal initiation factor 2
-
 Saccharolobus solfataricus

General Information

EC Number General Information Comment Organism
3.6.5.3 additional information protein:ligand interactions and conformational changes by molecular dynamics and Monte Carlo simulations, overview Saccharolobus solfataricus
3.6.5.3 physiological function archaeal initiation factor 2 is a protein involved in the initiation of protein biosynthesis. In its GTP-bound, ON conformation, aIF2 binds an initiator tRNA and carries it to the ribosome. In its GDP-bound, OFF conformation, it dissociates from tRNA, molecular dynamics, overview. AIF2 is largely responsible for recruiting the first, initiator tRNA to the ribosome and positioning it correctly, in register with the start codon of the ribosome-bound mRNA Saccharolobus solfataricus