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Literature summary extracted from

  • Chiou, C.H.; Lee, L.W.; Owens, S.A.; Whallon, J.H.; Klomparens, K.L.; Townsend, C.A.; Linz, J.E.
    Distribution and sub-cellular localization of the aflatoxin enzyme versicolorin B synthase in time-fractionated colonies of Aspergillus parasiticus (2004), Arch. Microbiol., 182, 67-79.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.143 expression in Escherichia coli Aspergillus parasiticus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.143 cytoplasm enzyme distributes throughout the cytoplasm and concentrates in ring-like structures surrounding nuclei Aspergillus parasiticus 5737
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Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.1.143 72000
-
 x * 72000, and x * 78000, SDS-PAGE Aspergillus parasiticus
4.2.1.143 78000
-
 x * 72000, and x * 78000, SDS-PAGE Aspergillus parasiticus

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.143 Aspergillus parasiticus Q12062
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.143 cell culture highest abundance of enzyme in colony fraction S2 consisting of cells that have grown for 24-48 h Aspergillus parasiticus
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4.2.1.143 conidiophore asexual developmental structures Aspergillus parasiticus
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4.2.1.143 hypha vegetative hyphae Aspergillus parasiticus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.143 versiconal i.e. (2S,3S)-2,4,6,8-tetrahydroxy-3-(2-hydroxyethyl)anthra[2,3-b]furan-5,10-dione Aspergillus parasiticus versicolorin B + H2O (3aR,12bS)-8,10,12-trihydroxy-1,2,3a,12b-tetrahydroanthra[2,3-b]furo[3,2-d]furan-6,11-dione ?

Subunits

EC Number Subunits Comment Organism
4.2.1.143 ? x * 72000, and x * 78000, SDS-PAGE Aspergillus parasiticus

General Information

EC Number General Information Comment Organism
4.2.1.143 physiological function enzyme catalyzes bisfuran ring closure in versiconal hemiacetal to form versicolorin B. This reaction is required for the subsequent activation to aflatoxin B1-8,9 epoxide, a highly reactive and toxic aflatoxin metabolite Aspergillus parasiticus