Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hasan, N.M.; Longacre, M.J.; Seed Ahmed, M.; Kendrick, M.A.; Gu, H.; Ostenson, C.G.; Fukao, T.; MacDonald, M.J.
    Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells (2010), Arch. Biochem. Biophys., 499, 62-68.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.3.5 expressed in INS-1832/13 cells Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.3.5 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.3.5 succinyl-CoA + acetoacetate Rattus norvegicus
-
 succinate + acetoacetyl-CoA
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.8.3.5 Rattus norvegicus B2GV06
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.3.5 pancreatic islet
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.3.5 succinyl-CoA + acetoacetate
-
 Rattus norvegicus succinate + acetoacetyl-CoA
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.8.3.5 SCOT
-
 Rattus norvegicus
2.8.3.5 succinyl-CoA:3-ketoacid-CoA transferase
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.8.3.5 malfunction insulinoma cell lines with more than 70% knockdown of enzyme activity shows more than 70% reduction in glucose- or methyl succinate-plus-beta-hydroxybutyrate-stimulated insulin release Rattus norvegicus