EC Number | Cloned (Comment) | Organism |
---|---|---|
1.10.5.1 | expression of recombinant QR2 in Spodoptera frugiperda Sf9 cells using the baculovirus transfection method | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.10.5.1 | Melatonin | - |
Homo sapiens | |
1.10.5.1 | additional information | inhibitor binding structures, overview | Homo sapiens | |
1.10.5.1 | resveratrol | - |
Homo sapiens | |
1.10.5.1 | S26695 | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.10.5.1 | cytosol | - |
Homo sapiens | 5829 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.10.5.1 | 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone | Homo sapiens | - |
1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.10.5.1 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.10.5.1 | additional information | QR2 is overexpressed in neurodegenerative diseases | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.10.5.1 | 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone | - |
Homo sapiens | 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone | - |
? | |
1.10.5.1 | additional information | quinone reductase 2 (QR2) is implicated in the reduction of quinone in the presence of natural derivatives of NADH such as N-ribosyldihydronicotinamide. QR2 does not recognize NADH or NADPH as co-substrates, unlike quinone reductase 1 (QR1) | Homo sapiens | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.10.5.1 | homodimer | - |
Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.10.5.1 | quinone reductase 2 | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.10.5.1 | 25 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.10.5.1 | 8.5 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.10.5.1 | FAD | flavoenzyme, binding structure, overview. 2 molecules per enzyme dimer, quantification, overview | Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.10.5.1 | malfunction | specific inhibitors of QR2, tested in vivo, show outstanding properties impairing memory loss | Homo sapiens |
1.10.5.1 | additional information | QR2 does not share many features with QR1. Particularly, it does not seem to have a similar detoxifying function in cells. QR2 is overexpressed in neurodegenerative diseases | Homo sapiens |