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Literature summary extracted from

  • Chen, X.; Overcash, R.; Green, T.; Hoffman, D.; Asch, A.S.; Ruiz-Echevarria, M.J.
    The tumor suppressor activity of the transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) correlates with its ability to modulate sarcosine levels (2011), J. Biol. Chem., 286, 16091-16100.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.5.8.3 TMEFF2 i.e. full-length follistatin motifs 2, the enzyme interacts with the full-length follistatin motifs 2, TMEFF2. TMEFF2 has a dual mode of action. The ectodomain does not bind to SARDH. Ectopic expression of wild-type full-length TMEFF2 inhibits soft agar colony formation, cellular invasion, and migration and increases cellular sensitivity to apoptosis. Expression of the full-length TMEFF2 but not the ectodomain results in a decreased level of sarcosine in the cells Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.8.3 expression of Myc- and His-tagged enzyme in HEK-293T cells, co-exxpression with TMEFF2, phenotype, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.8.3 sarcosine + H2O + electron-transfer flavoprotein Homo sapiens
-
 glycine + formaldehyde + reduced electron-transfer flavoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.8.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.8.3 brain
-
 Homo sapiens
-
1.5.8.3 prostate
-
 Homo sapiens
-
1.5.8.3 prostate gland cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.8.3 sarcosine + H2O + electron-transfer flavoprotein
-
 Homo sapiens glycine + formaldehyde + reduced electron-transfer flavoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.8.3 SARDH
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.8.3 electron transferring flavoprotein
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.5.8.3 Homo sapiens overexpression of TMEFF2 activates the enzyme activity but does not affect its expression level additional information

General Information

EC Number General Information Comment Organism
1.5.8.3 metabolism TMEFF2 interacts with SARDH and regulates the cellular levels of sarcosine. The tumor suppressor activity of TMEFF2 requires the cytoplasmic/transmembrane portion of the protein and correlates with its ability to bind to SARDH and to modulate the level of sarcosine Homo sapiens
1.5.8.3 additional information the enzyme interacts with the full-length follistatin motifs 2, TMEFF2. TMEFF2 has a dual mode of action. The ectodomain does not bind to SARDH. Ectopic expression of wild-type full-length TMEFF2 inhibits soft agar colony formation, cellular invasion, and migration and increases cellular sensitivity to apoptosis. Expression of the full-length TMEFF2 but not the ectodomain results in a decreased level of sarcosine in the cells Homo sapiens