EC Number | Application | Comment | Organism |
---|---|---|---|
1.17.4.4 | medicine | the enzyme is regulated by microRNA miR-133a, which may have potential importance for anticoagulant therapy or aortic calcification | Homo sapiens |
1.17.4.4 | medicine | vitamin K 2,3-epoxide reductase complex subunit 1 is is the target of oral anticoagulant drugs and a relevant molecule for cardiovascular diseases | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.17.4.4 | gene rs9923231 or VKORC1, genotyping of rs9923231, quantitative RT-PCR expression analysis | Homo sapiens |
1.17.4.4 | gene rs9923231, quantitative reverse transcriptasePCR expression analysis | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.17.4.4 | miR-133a | micro-RNA, miR-133a interacts with the 3'-UTR of VKORC1. Transfection of miRNA precursors of miR-133a in HepG2 cells reduces VKORC1 mRNA expression in a dose-dependent manner, quantitative RT-PCR expression analysis, overview. miR-133a levels correlate inversely with VKORC1 mRNA levels in 23 liver samples from healthy subjects. In silico identification of VKORC1 miRNA binding sites, overview | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.17.4.4 | membrane | - |
Homo sapiens | 16020 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | Homo sapiens | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.4.4 | Homo sapiens | Q6BQB6 | gene rs9923231 or VKORC1 | - |
1.17.4.4 | Homo sapiens | Q9BQB6 | gene rs9923231 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.17.4.4 | HEK-293T cell | - |
Homo sapiens | - |
1.17.4.4 | Hep-G2 cell | - |
Homo sapiens | - |
1.17.4.4 | liver | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.4.4 | 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O | - |
Homo sapiens | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.17.4.4 | vitamin K 2,3-epoxide reductase complex subunit 1 | - |
Homo sapiens |
1.17.4.4 | VKORC1 | - |
Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.17.4.4 | Homo sapiens | miR-133a miRNA targeting the enzyme in HepG2 cells reduces VKORC1 mRNA expression in a dose-dependent manner, quantitative reverse transcriptasepolymerase chain reaction expression analysis. miR-133a interacts with the 3'-UTR of VKORC1 | down |
1.17.4.4 | Homo sapiens | micro-RNA miR-133a interacts with the 3'-UTR of VKORC1. Transfection of miRNA precursors of miR-133a in HepG2 cells reduces VKORC1 mRNA expression. miR-133a levels correlate inversely with VKORC1 mRNA levels in 23 liver samples from healthy subjects | down |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.17.4.4 | physiological function | the enzyme is regulated by microRNA miR-133a, which may have potential importance for anticoagulant therapy or aortic calcification. miR-133a levels correlate inversely with VKORC1 mRNA levels in 23 liver samples from healthy subjects | Homo sapiens |
1.17.4.4 | physiological function | VKORC1 is an essential element involved in the correct gamma-carboxylation of vitamin K-dependent proteins such as Gas6, matrix-GLA protein and osteocalcin, as well as hemostatic proteins C, S and Z and coagulation factors II, VII, IX and X. vitamin K 2,3-epoxide reductase complex subunit 1, VKORC1, is a key protein in the vitamin K cycle, it is regulated by microRNA miR-133a, overview. Vitamin K 2,3-epoxide reductase complex subunit 1 is a relevant molecule for cardiovascular diseases, since it plays a role in soft tissue calcification | Homo sapiens |