EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.3.3.12 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.3.12 | 4-hydoxyphenylpyruvate | - |
Homo sapiens | ? | - |
? | |
5.3.3.12 | D-dopachrome | - |
Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.3.3.12 | Macrophage migration inhibitory factor | - |
Homo sapiens |
5.3.3.12 | MIF | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
5.3.3.12 | physiological function | the enzyme binds to the type II transmembrane protein, CD74, leading to its intracellular phosphorylation, the recruitment of the coreceptor CD44, and the activation of SRC family kinases and the ERK1/2 MAPK pathway. The enzyme counterregulates the inhibitory effect of glucocorticoids on tissue necrosis factor production from lipopolysaccharide-stimulated macrophages | Homo sapiens |