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Literature summary extracted from
- Physiological regulation of lipoprotein lipase (2014), Biochim. Biophys. Acta, 1841, 919-933.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.34 | angiopoietin-like protein 4 | major physiological regulator of enzyme activity under conditions of fasting and exercise | Mus musculus | |
| 3.1.1.34 | apolipoprotein A5 | - |
Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.34 | ANGPTL4 | conventional, non-competitive inhibitor | Mus musculus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.34 | triacylglycerol + H2O | Mus musculus | - |
diacylglycerol + a carboxylate | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.34 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.34 | brain | - |
Mus musculus | - |
| 3.1.1.34 | brown adipose tissue | - |
Mus musculus | - |
| 3.1.1.34 | heart | - |
Mus musculus | - |
| 3.1.1.34 | kidney | - |
Mus musculus | - |
| 3.1.1.34 | liver | - |
Mus musculus | - |
| 3.1.1.34 | lung | - |
Mus musculus | - |
| 3.1.1.34 | macrophage | - |
Mus musculus | - |
| 3.1.1.34 | mammary gland | - |
Mus musculus | - |
| 3.1.1.34 | skeletal muscle | - |
Mus musculus | - |
| 3.1.1.34 | white adipose tissue | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.34 | triacylglycerol + H2O | - |
Mus musculus | diacylglycerol + a carboxylate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.1.34 | dimer | - |
Mus musculus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.34 | LPL | - |
Mus musculus |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 3.1.1.34 | Mus musculus | stress and catecholamines reduce adipose enzyme activity. Tissue necrosis factpor alpha represses enzyme activity by downregulating transcription | down |
| 3.1.1.34 | Mus musculus | insulin, dexamethasone and cortisol increase mRNA and activity in adipose organs. Cold markedly stimulates enzyme activity in brown adipose tissue | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.1.1.34 | physiological function | the enzyme is rate limiting for plasma triglyceride clearance and tissue uptake of fatty acids | Mus musculus |
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Release 2023.1 (January 2023)
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