EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.3 | CGI-58 | co-activator | Mus musculus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.1.3 | expressed in in Cos-7 cells | Mus musculus |
3.1.1.79 | recombinant expression of His-tagged enzyme | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.79 | 76-0079 | a commercial small molecule inhibitor | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.1.79 | cytosol | - |
Mus musculus | 5829 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.3 | additional information | Mus musculus | the enzyme hydrolyzes long-chain fatty acid esters in vivo with a modest substrate preference for C16:1 | ? | - |
? | |
3.1.1.3 | additional information | Mus musculus C57BL/6 | the enzyme hydrolyzes long-chain fatty acid esters in vivo with a modest substrate preference for C16:1 | ? | - |
? | |
3.1.1.3 | triacylglycerol + H2O | Mus musculus | - |
diacylglycerol + a carboxylate | the enzyme specifically generates sn-1,3 and, in the presence of its co-activator CGI-58, sn-1,3 and sn-2,3 diacylglycerol | ? | |
3.1.1.3 | triacylglycerol + H2O | Mus musculus C57BL/6 | - |
diacylglycerol + a carboxylate | the enzyme specifically generates sn-1,3 and, in the presence of its co-activator CGI-58, sn-1,3 and sn-2,3 diacylglycerol | ? | |
3.1.1.79 | diacylglycerol + H2O | Mus musculus | - |
monoacylglycerol + a carboxylate | - |
? | |
3.1.1.79 | additional information | Mus musculus | sn-1,3-diacylglycerol is the preferred substrate for the consecutive hydrolysis by hormone-sensitive lipase, the enzyme is less active with sn-1,2-diacylglycerol | ? | - |
? | |
3.1.1.79 | triacylglycerol + H2O | Mus musculus | - |
diacylglycerol + a carboxylate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.3 | Mus musculus | - |
- |
- |
3.1.1.79 | Mus musculus | - |
- |
- |
3.1.1.79 | Mus musculus C57BL/6 | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.79 | white adipose tissue | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.3 | additional information | the enzyme hydrolyzes long-chain fatty acid esters in vivo with a modest substrate preference for C16:1 | Mus musculus | ? | - |
? | |
3.1.1.3 | additional information | the enzyme hydrolyzes long-chain fatty acid esters in vivo with a modest substrate preference for C16:1 | Mus musculus C57BL/6 | ? | - |
? | |
3.1.1.3 | triacylglycerol + H2O | - |
Mus musculus | diacylglycerol + a carboxylate | the enzyme specifically generates sn-1,3 and, in the presence of its co-activator CGI-58, sn-1,3 and sn-2,3 diacylglycerol | ? | |
3.1.1.3 | triacylglycerol + H2O | - |
Mus musculus C57BL/6 | diacylglycerol + a carboxylate | the enzyme specifically generates sn-1,3 and, in the presence of its co-activator CGI-58, sn-1,3 and sn-2,3 diacylglycerol | ? | |
3.1.1.3 | trilinolein + H2O | lowest activity | Mus musculus | ? | - |
? | |
3.1.1.3 | trilinolein + H2O | lowest activity | Mus musculus C57BL/6 | ? | - |
? | |
3.1.1.3 | trilinolenin + H2O | - |
Mus musculus | ? | - |
? | |
3.1.1.3 | trilinolenin + H2O | - |
Mus musculus C57BL/6 | ? | - |
? | |
3.1.1.3 | triolein + H2O | - |
Mus musculus | ? | - |
? | |
3.1.1.3 | triolein + H2O | - |
Mus musculus C57BL/6 | ? | - |
? | |
3.1.1.3 | tripalmitolein + H2O | highest activity | Mus musculus | ? | - |
? | |
3.1.1.79 | diacylglycerol + H2O | - |
Mus musculus | monoacylglycerol + a carboxylate | - |
? | |
3.1.1.79 | additional information | sn-1,3-diacylglycerol is the preferred substrate for the consecutive hydrolysis by hormone-sensitive lipase, the enzyme is less active with sn-1,2-diacylglycerol | Mus musculus | ? | - |
? | |
3.1.1.79 | triacylglycerol + H2O | - |
Mus musculus | diacylglycerol + a carboxylate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.1.3 | adipose triglyceride lipase | - |
Mus musculus |
3.1.1.3 | ATGL | - |
Mus musculus |
3.1.1.79 | HSL | - |
Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.1.79 | malfunction | enzyme-deficient mice accumulate sn-1,3-diacylglycerol and sn-2,3-diacylglycerol in white adipose tissue | Mus musculus |
3.1.1.79 | physiological function | the enzyme is crucial for the hydrolysis of diacylglycerol within the lipolytic cascade | Mus musculus |